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Old 11-28-2012
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Default Renal Tubular Acidosis help?

Please someone mind explaining...

What I get from RTA type 1 is it no longer has a function H/K pump. So the K can't be reabsorbed into the interstitium and the H can't be excreted out.
Causing hypokalemia and non-anion gap Acidosis.
Then DIT went to say the pH would be greater then 5.3.
But if RTA type 1 is associated with Calcium stones and they are precipitated with lower pH why do they occur?

I also have am confused on why Type 4 RTA would inhibit ammonium excretion and decrease synthesis of new bicarb.

Someone please mind clearing this up!!
PLeasee:co nfused:
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Old 11-29-2012
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Quote:
Originally Posted by SOBE223 View Post
Please someone mind explaining...

What I get from RTA type 1 is it no longer has a function H/K pump. So the K can't be reabsorbed into the interstitium and the H can't be excreted out.
Causing hypokalemia and non-anion gap Acidosis.
Then DIT went to say the pH would be greater then 5.3.
But if RTA type 1 is associated with Calcium stones and they are precipitated with lower pH why do they occur?

I also have am confused on why Type 4 RTA would inhibit ammonium excretion and decrease synthesis of new bicarb.

Someone please mind clearing this up!!
PLeasee:co nfused:
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SOBE223 (11-29-2012)
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Old 11-29-2012
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Thanks!
There was also a mistake in FA that was corrected in the errata that I somehow skipped that cleans up my confusion.
Calcium phosphate precipitates at increase pH. While Calcium Oxalate precipitates at decreased pH.
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Old 12-17-2012
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Quote:
Originally Posted by SOBE223 View Post
Thanks!
There was also a mistake in FA that was corrected in the errata that I somehow skipped that cleans up my confusion.
Calcium phosphate precipitates at increase pH. While Calcium Oxalate precipitates at decreased pH.
Heyy which errata are you using? I have fa 2012 and RTA is explained on Pg 514, but the errata for it has no corrections on this page??
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Old 12-17-2012
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Yes RTAs are discussed on pg 514 but regarding the pH and stone formation is on page 519 which is in the errata.
(1) In the first row, the second column: Calcium oxalate stones precipitate at normal or ↓ pH; calcium phosphate stones precipitate at ↑ pH.
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