I always forget the differences between pemphigus and pemphigoid - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 08-30-2010
USMLE Forums Scout
 
Steps History: Not yet
Posts: 49
Threads: 20
Thanked 28 Times in 6 Posts
Reputation: 38
Skin I always forget the differences between pemphigus and pemphigoid

Hey
Can any body clear me the differences between Bullous pemphigoid n pemphigus vulgaris. I always understand n learn n I always forget...........................................: confused:
Reply With Quote Quick reply to this message



  #2  
Old 08-30-2010
USMLE Forums Veteran
 
Steps History: 1 + CS
Posts: 216
Threads: 56
Thanked 116 Times in 56 Posts
Reputation: 116
Cool Good question!

I always found this little chart helpful, hope this helps you also, and i'm already taking into account that you sort of know what they are already...

Characteristics
Pemphigus vulgaris Bullous pemphigoid

Age= Middle age, Elderly
Clinical Features = Monomorphic Polymorphic
Blisters= Rupture easily, Flaccid Tense, firm
Content of Blisters= fluid filled often hemorrhagic
Oral Lesions= Common Rare
Nikolsky's sign= Positive Negative
Tzanck smear= Acantholysis No Acantholysis
D. Immunoflourescence= Intraepidermal deposits Deposits at the epidermal basement membrane
zone= Target antigen Desmoglein 1 & 3 BPAG2- -(type 17 collagen)

though for some reason i couldn't get it exactly in a table form, but i color coded it so it'll be easier....also remember that Nikolsky's sign is positive when slight rubbing of the skin results in exfoliation of the skin's outermost layer.

hope this helps
Reply With Quote Quick reply to this message
The above post was thanked by:
Dr. N Elham (08-30-2010), kaumudi (06-02-2016), khushboo (08-30-2010), Marinaa (10-23-2014), monsalg2502 (11-21-2011), osahon (01-08-2014), pretk (08-30-2010), raheel_memon (08-31-2010), Taayseer (02-15-2015)
  #3  
Old 08-31-2010
USMLE Forums Guru
 
Steps History: 1 + CK
Posts: 373
Threads: 30
Thanked 375 Times in 160 Posts
Reputation: 385
Smile

I found this helpful thought i should share.....

Pemphigus vulgaris vs Bullous pemphigoid

PemphiguS = Superficial

PemphigoiD= Deep


PemphiguS = Superficial Separation => Intraepidermal Acantholysis => Flaccid bullae that rupture easily => Infection=> death if not treated.


PemphigoiD= Deep epidermal junction => Tense bullae that don't rupture easily => Heal without scarring
__________________
Knowing is not enough; we must apply.
Willing is not enough; we must do.
Reply With Quote Quick reply to this message
The above post was thanked by:
kaumudi (06-02-2016), khushboo (08-31-2010), Marinaa (10-23-2014), monsalg2502 (09-20-2011), Taayseer (02-15-2015), Usmle16Forall (04-28-2016)
 
  #4  
Old 09-01-2010
USMLE Forums Guru
 
Steps History: 1+CK+CS+3
Posts: 363
Threads: 18
Thanked 311 Times in 149 Posts
Reputation: 321
Default

I always remember it like this to get me started. Like on the test, I'm not going to sway, its going to be clear cut / black and white


pemphigus vulgaris- is vulgar, meaning swears a lot/mouthy. Blisters in the mouth and mucus. Because the blisters go in more places its going to have a more serious effect. then add AB against desmosomes, circular immunoflurescence, in epidermis, oral lesions.

Key to know: AB against Desmosomes, oral lesions in mouth



Bullous pemphigoid- is only on the skin. Ab against hemidesmosomes, linear immunofluoresence, subepidermal, floating keratinocytes

Key to know: AB against hemidesmosomes, no blisters in oral/mucosa


They will ask you a clinical question, something like;

a 4 year old girl started to have blisters on her skin that slough off easy, when you exam her you noticed blisters in the mouth. You run some tests and see there are some circular immunoflurence, what else would you see?

A) AB against desmosomes
B) floating keratinocytes
C) Ab against hemidesmosomes
D) Double Stranded DNA virus
Reply With Quote Quick reply to this message
The above post was thanked by:
Marinaa (10-23-2014), shine4ever (01-18-2014), step1an (09-01-2010)
  #5  
Old 09-01-2010
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 3,316
Threads: 170
Thanked 4,901 Times in 1,809 Posts
Reputation: 4954
Link Another useful thread

This may also help
http://www.usmle-forums.com/usmle-st...emphigoid.html
Reply With Quote Quick reply to this message
The above post was thanked by:
Usmle16Forall (04-28-2016)



Reply

Tags
Pathology-, Skin-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Dear IMGs ... Forget Univesities Matching Ambrogio IMG/FMG Forum 9 02-03-2012 11:07 PM
If you are a Muslim, forget about USMLE MhmdAli General Topics Forum 4 05-25-2010 02:11 AM
Pemphigus Vulgaris Versus Bullous Pemphigoid rasheed USMLE Step 1 Bits & Pieces 3 12-17-2009 01:21 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)