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Old 12-04-2012
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Default Microbiology whooping cough question

A child of an immigrant is suffering with repetitive cough with whoops, vomiting and leukocytosis.
Nasopharyngeal Culture in the Bordet-Gengou medium is negative, but Direct immunofluorescence on nasopharyngeal smear is positive for Bordetella pertussis. Studies have shown that one of the toxins produced by Bordetella impairs leukocute chemotaxis, which of the following toxin is responsible for impairment of leukocyte chemotaxis?

A) Adenylate cyclase toxin

B) Tracheal cytotoxin

C) Pertussis toxin A component

D) Pertussis toxin B component

E) Endotoxin

Last edited by nuziveed; 12-04-2012 at 08:17 PM.
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Old 12-04-2012
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Default my answer :)

A) Adenylate cyclase toxin
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Old 12-04-2012
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Originally Posted by nuziveed View Post
A child of an immigrant is suffering with repetitive cough with whoops, vomiting and leukocytosis.
Nasopharyngeal Culture in the Bordet-Gengou medium is negative, but Direct immunofluorescence on nasopharyngeal smear is positive for Bordetella pertussis. Studies have shown that one of the toxins produced by Bordetella impairs leukocute chemotaxis, which of the following toxin is responsible for impairment of leukocyte chemotaxis?

A) Adenylate cyclase toxin

B) Tracheal cytotoxin

C) Pertussis toxin A component

D) Pertussis toxin B component

E) Endotoxin

A) Adenylate cyclase toxin

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Old 12-06-2012
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Quote:
Originally Posted by nuziveed View Post
A child of an immigrant is suffering with repetitive cough with whoops, vomiting and leukocytosis.
Nasopharyngeal Culture in the Bordet-Gengou medium is negative, but Direct immunofluorescence on nasopharyngeal smear is positive for Bordetella pertussis. Studies have shown that one of the toxins produced by Bordetella impairs leukocute chemotaxis, which of the following toxin is responsible for impairment of leukocyte chemotaxis?

A) Adenylate cyclase toxin

B) Tracheal cytotoxin

C) Pertussis toxin A component

D) Pertussis toxin B component

E) Endotoxin

Adenylate cyclase toxin inhibits production of interleukin which results in impairment of chemotaxis.
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