Embryo Question. Homeobox gene. Level of detail we should know? - USMLE Forums
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Old 12-06-2012
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Default Embryo Question. Homeobox gene. Level of detail we should know?

Just scanning through embryo right now (FIRST AID), to get a flavor of what we need to know.

For Homeobox gene, it says "involved in segmental organization".

do we need to know about the genes themseleves, how they work? the homeodomain, and dna transcription factors?

or is it sufficient to just know what first aid has - just that its involved in segmental organization (crania-caudal i believe)
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Old 12-06-2012
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The LATTER you need to know
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Old 12-06-2012
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Hemeobox (HOX)
1- Blue print for skeletal morphology
2- Code for transcription regulators (I saw this in Uworld Q)
3- Mutation in homeobox HOXD-13--> synpalydactyly between 3rd and 4th fingers.(uworld also)
4- Retinoic acid alters gene expression. (Goes with 2nd bullet).

It think that is all you have to know. The questions are twisted, they will give you the signs and they will ask you to recall what gene it is.

Good luck.
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