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Old 12-08-2012
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Liver Lab test to estimate Chronic Liver Damage

A 49-year-old alcoholic presented with features of acute fulminant hepatic failure. The figure shows the cut surface of the liver removed at autopsy. The underlying chronic damage to the liver could have been picked up during life by estimating what?

A. Alanine aminotransferase
B. Serum albumin
C. Serum alkaline phosphatase
D. Serum conjugated bilirubin
E. Serum unconjugated bilirubin

the picture showed some kind a fibrosis
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Old 12-08-2012
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I would go with option b albumin .....
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Old 12-08-2012
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B
U world Q# 1423:
Alcoholic liver injury develops through the stages of alcoholic steatosis, alcoholic hepatitis and cirrhosis. Increased AST and ALT are indications of hepatocellular damage. The serum albumin level and prothrombin time reflect liver function and are of greatest prognostic significance.

Pretty much Hypoalbuminemia and prolonged PT.
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Old 12-08-2012
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yea thankz gyz was wondering why not ast/alt bcoz that cold occur and the explanation doesn't hint much on that...
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Old 12-08-2012
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Obinocle, elevated AST/ALT show acute damage to cells, cell lysis and elevated enzyme level in blood. In chronic condition damage has already occurred and cell have stopped normal function. Production of albumin and clotting factor is normal function of liver cell, there decreased amount will be showing that how severe damage has occur.
I think have made it clear, as mnot good at explaining.
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