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Old 12-17-2012
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Default Gs or Gi coupled receptor?

Hi,

i was just wondering if the following receptors were Gs or Gi coupled?

LH, FSH, ACTH,Epineph, Secretin, HCG, Calcitonin, PTH, GH,, TSH, CRH GHRH
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Old 12-18-2012
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Default my answer is Gs

coz they all are stimulatory agonists so must be coupled to Gs
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Old 12-21-2012
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Quote:
Originally Posted by tarsuc View Post
Hi,

i was just wondering if the following receptors were Gs or Gi coupled?

LH, FSH, ACTH,Epineph, Secretin, HCG, Calcitonin, PTH, GH,, TSH, CRH GHRH
A few that am sure of are the following...
Cytokines,colony stimulating factors,Growth hormone,Prolactin,IL2 use the JAK/STAT pathway
Oxytocin,GHRH,GnRH,TRH,Angiotensin 2,M1 and M3,V1 and V3,Alpha 1 are Gq coupled.
Gi includes Alpha 2,M2,V2
Gs includes Beta 1 and 2,Glucagon,PTH etc
The list is long.Am sure you can add to it as you study along...
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