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  #1  
Old 12-29-2012
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Drug Bioavailbility of isosrbide mononitrate

bioavailbility of isosrbide mononitrate is 100% then what will be the bioavailbility of the sublingual nitroglycerin
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Old 12-29-2012
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I think .. because isosrbinde mononitrate is an active metabolite ,so it does not under go first pass metabolism ..where as nitroglycerin is not an active metabolite.... let me know if i'm wrong ..thanks
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Old 12-30-2012
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Originally Posted by dr,maps View Post
I think .. because isosrbinde mononitrate is an active metabolite ,so it does not under go first pass metabolism ..where as nitroglycerin is not an active metabolite.... let me know if i'm wrong ..thanks
you are right,ya isosorbide mononitrate is an active metabolic product of isosorbide dinitrate which goes thru first pass metabolism,and it has 100%bioavailability but what about nitroglycerin given sublingualy from there it directly enters into the systmic circulation then bioavailability should be 100% not less then that am i right
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Old 01-08-2013
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Quote:
Originally Posted by neha_subh View Post
you are right,ya isosorbide mononitrate is an active metabolic product of isosorbide dinitrate which goes thru first pass metabolism,and it has 100%bioavailability but what about nitroglycerin given sublingualy from there it directly enters into the systmic circulation then bioavailability should be 100% not less then that am i right
even i think its 100%.. coz it does not have first pass met.. hence once the effect is achieved the patient can spit it out..
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Old 01-08-2013
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Originally Posted by nandish_m View Post
even i think its 100%.. coz it does not have first pass met.. hence once the effect is achieved the patient can spit it out..
its bioavailability less then 100% uw concept, its bioavailability is around 40-50% according to wikipedia
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Old 01-09-2013
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Quote:
Originally Posted by neha_subh View Post
its bioavailability less then 100% uw concept, its bioavailability is around 40-50% according to wikipedia
can u plz further explain it as m bit confused
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Old 01-09-2013
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Originally Posted by sanobar View Post
can u plz further explain it as m bit confused
i dont know why its bioavailability less not 100% thats why i have asked,am also confused.please visit wikipedia for that
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Quote:
Originally Posted by neha_subh View Post
i dont know why its bioavailability less not 100% thats why i have asked,am also confused.please visit wikipedia for that
i think this question wont come.. lol
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Old 01-09-2013
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Originally Posted by nandish_m View Post
i think this question wont come.. lol
ya you are right,just remember that its bioavailability not 100%
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