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Old 12-31-2012
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Angry dyskinesia - Due to Ach or dopamine

This is beginning to get really confusing.

What causes dyskinesia?
Acetyl choline or due to dopamine

Could someone please explain this to me?

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Old 12-31-2012
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Ach causes muscular rigidity-akinesia
Dopamine increases movement-akathisia
There should be increase dopaminergic system causing dyskinesia
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Default confused

Thanks a lot for your reply,

But i was wondering then

how would muscarinic blockers help in treating Extrapyramidal symptoms? (i understand how it would help akinesia, but how can it help in akathisia and dyskinesia)

Or is my concept wrong here.
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Quote:
Originally Posted by tarsuc View Post
Thanks a lot for your reply,

But i was wondering then

how would muscarinic blockers help in treating Extrapyramidal symptoms? (i understand how it would help akinesia, but how can it help in akathisia and dyskinesia)

Or is my concept wrong here.
Muscarinic blockers relieve dystonia and pain caused from sustained muscle contraction
concerning akathisia and later dyskinesia as far as i know are dopamine induced and ach is not helpful (when neuroleptics are used in the begining the dopamine antagonism causes unnoposed ach action when we can use muscarinic blockers
later-sensitization of dopamine receptors cause akathisia and if neuroleptics are not discontinued then dyskinesia which is due to upregulation of dopamine receptors)
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Last edited by MedicalExaminer; 12-31-2012 at 08:16 AM.
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