Cortisol Stress Hormone or Immune Suppressant! - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 01-10-2013
USMLE Forums Guru
 
Steps History: Not yet
Posts: 315
Threads: 115
Thanked 160 Times in 85 Posts
Reputation: 170
Question Cortisol Stress Hormone or Immune Suppressant!

I know I'm missing something obvious, hoping someone can point it out. I'm now doing a systems review!

Currently on the Endocrine section, and can't seem to figure this out. On one hand, Cortisol is secreted during times of severe stress (eg. Infection). But Cortisol is a Glucocorticoid, which are known to SUPPRESS the immune system. So how does Cortisol help fight infections, when the immune system is suppressed?

Thanks!
Reply With Quote Quick reply to this message
The above post was thanked by:
5hstar (01-17-2013)



  #2  
Old 01-10-2013
USMLE Forums Guru
 
Steps History: Not yet
Posts: 315
Threads: 115
Thanked 160 Times in 85 Posts
Reputation: 170
Default

This is guess btw, but is the mechanism because it suppresses the immune response to the infection?

What I mean is this: is the response to the immune system 'suppressed' (by cortisol) to not overact?
Reply With Quote Quick reply to this message
  #3  
Old 01-10-2013
MedicalExaminer's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 824
Threads: 66
Thanked 463 Times in 298 Posts
Reputation: 473
Default

Cortisols natural function is to prepare body for stress by mobilizing fat and supplying glucose to body
So far i have never heard that body can use it for immune modulation (except for its artificial uses)
__________________
Everything is possible for him who believes (MARK 9:23)
245/247/passed on 1st attempt/223/2mos Obsie /3 US LORS/visa not needed/2008 grad
Reply With Quote Quick reply to this message
 
  #4  
Old 01-16-2013
USMLE Forums Addict
 
Steps History: Not yet
Posts: 164
Threads: 35
Thanked 147 Times in 47 Posts
Reputation: 157
Default

Cortisol is one of the four stress hormones (the others being GH, Glucagon and Epi). By definition, a stress hormone is released to make sure that your body has enough sugar to fight off the stressor (infection, injury etc). The way cortisol mediates its immunosuppressive effect is through leukocytosis. In order to understand this effect, you must know that in the human body at any given point in time, there are two populations of leukocytes: A circulating population (which you measure in your blood) and a marginating population (which hangs out in tissues). I believe the percentage of circulating/marginating cells is about 50/50 in a healthy individual. But if that individual gets infected with a microbe, his or her circulating pool tends to decrease becuase now more cells are needed at the site of infection. The way these cells make it from the bloodstream to the tissue is through adhesion molecules known as Integrins. Cortisol tends to inhibit the expression of these molecules by leukocytes so that they're not able to move from the blood to the infected tissue. This means that a person taking cortisol is going to have an INCREASED number of leukocytes in their plasma.
__________________
you don't get what you wish for, you get what you work for
Reply With Quote Quick reply to this message
The above post was thanked by:
5hstar (01-17-2013), kalampakas (10-21-2013)
  #5  
Old 10-20-2013
USMLE Forums Newbie
 
Steps History: CK Only
Posts: 2
Threads: 0
Thanked 0 Times in 0 Posts
Reputation: 10
Default my question- cortisol-insulin

if cortisol inhibits insulin's effect, and insulin induces glucose movement into the cell ,then how cortisol helps in fulfilling energy demand by glucose, wouldn't glucose just satay in blood stream, and not in the cell where its needed.
Reply With Quote Quick reply to this message
  #6  
Old 11-26-2016
USMLE Forums Newbie
 
Steps History: ---
Posts: 4
Threads: 3
Thanked 0 Times in 0 Posts
Reputation: 10
Default

I know it is probably late but I thought of posting an explanation in case anyone was searching for this. One of the main purposes of cortisol is to provide enough glucose for brain neurons in times of stress. These neurons have glucose transporters that are not affected by insuline levels which means that their gluose uotake is not dependent on insuline. This is why even though cortisol decreases glucose uptake in most tissues it actually helps to provide more glucose to the brain.
Reply With Quote Quick reply to this message



Reply

Tags
Endocrine-, Immunology-, Physiology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Cortisol Effects on Bones struggle USMLE Step 1 Forum 12 11-28-2014 11:15 AM
what is role of stress hormone on proteins... doubt regarding cushing and acromegaly...please help. tyagee USMLE Step 1 Forum 1 06-25-2012 07:33 AM
Which one alter Immune system ? aungawa USMLE Step 1 Forum 8 11-20-2011 04:14 AM
Cortisol and protein synthesis gear2d USMLE Step 1 Forum 1 09-24-2011 05:46 PM
u world questions:confusion regarding cortisol administration and T3 thyroide hormone administration. winner21 USMLE Step 1 Forum 1 07-03-2011 03:55 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)