minimal change disease - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

Thread Tools Search this Thread Display Modes
Old 01-13-2013
USMLE Forums Scout
Steps History: Not yet
Posts: 17
Threads: 17
Thanked 0 Times in 0 Posts
Reputation: 10
Default minimal change disease

Can't solve alone..

The proteinuria of MCD is selective, because of a decrease in the normal content of polyanion in the basement membrane.
In this part, not really understandable how the subsequent loss of negative charge may follow. (Largely albumin alone is lost.)

Could anyone help?
Reply With Quote Quick reply to this message

Old 01-14-2013
Master shifu's Avatar
USMLE Forums Addict
Steps History: Step 1 Only
Posts: 190
Threads: 14
Thanked 86 Times in 58 Posts
Reputation: 96

MCD which is the most common cause of nephrotic syndrome in children results from inappropriate immune activation that causes T cell activation & thereby releasing T-cell cytokines which leads to loss of polyanion i.e. negative charge of the GBM. As GBM loses it's negative charge so thereby it can't repulse the albumin which is also negatively charged. Consequently Selective Proteinuria occurs.
Reply With Quote Quick reply to this message
The above post was thanked by:
kang0162 (01-14-2013)


Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
Minimal effort to PASS step 1? AussieDoc USMLE Step 1 Forum 2 01-09-2013 10:04 PM
Minimal number of interviews to feel safe alanine40 IMG Residency Match Forum 0 10-30-2012 11:35 AM
Minimal step 1 books in Delhi pranav pandoh USMLE Step 1 Forum 0 09-13-2011 02:40 PM
cyanosis with minimal exertion usmleman2020 USMLE Step 1 Forum 3 08-05-2011 01:13 AM
SBP in minimal change disease FSUSTC USMLE Step 2 CK Forum 8 05-10-2010 05:29 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2016 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)