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Old 01-20-2013
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Question Serotonin 5-HT2A receptors!! location? function?

ok, i'm talking about the antagonist drugs, used to treat anxiety and depression: nefazodone and trazodone.

Where exactly are these RECEPTORS (5-HT2a) located? And when blocked, how do they create an increase of Serotonin in the synaptic cleft?

I understand the clever mechanism of action for Mirtazapine well. inhibits alpha 2 receptors on presynaptic neurons, which decreases negative feedback, which increases amine release. very sneaky, and very clever!

but what is the story with these 5-HT2a receptors!!!
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Old 01-20-2013
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Can u tell 5HT2 receptors cause vasoconstriction or vasodilation?
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Originally Posted by billy View Post
Can u tell 5HT2 receptors cause vasoconstriction or vasodilation?
smooth muscle contraction in gut, uterus, and some vessels, or relaxation in other vessels. several mechanisms involved: increased IP3, dec. K conductance, and dec. cAMP. receptor is probably responsible for some of the vasodilation, diarrhea, and bronchoconstriction occuring as symptoms of carinoid tumor.

(from katzung)


but i believe these are peripheral effects. and i think location/functions of receptors changes. yes, the mechanism of receptor may be the same, but the final output may be different, depending on if its CNS location, or peripheral location.
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