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Old 01-22-2013
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Default thalassemia

there are 2 gene that codes for alpha chains so there are 4 allleles when we take about disease we considere defect in allele like defect in 4 allele lead to hb barts but did anyone notice on first aid defect in 4 genes not alleles despite presence of 2 genes pllzzz which concept is correct????
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Old 01-22-2013
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2 copies of alpha on chromosome 16. And chromosome 16 from each parent gives you 4 alpha genes.
Delete 1 or 2genes gives you no anemia.
Delete 3 gives u hbH.
Delete 4 gives you hb Bart's.

Can go into a bit more detail with CIS and Trans deletions. But it shouldn't get more complicated then that.
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Old 01-22-2013
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Quote:
Originally Posted by SOBE223 View Post
2 copies of alpha on chromosome 16. And chromosome 16 from each parent gives you 4 alpha genes.
Delete 1 or 2genes gives you no anemia.
Delete 3 gives u hbH.
Delete 4 gives you hb Bart's.

Can go into a bit more detail with CIS and Trans deletions. But it shouldn't get more complicated then that.
ok so human has 4 gene (2 gene on each chromosome? and each gene code for 1 allele?
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