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Old 01-25-2013
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Question Metabolic Alkalosis

Excessive use of which of the following compounds may cause metabolic alkalosis?

1) Pirenzepine
2) Aluminum hydroxide
3) Cimetidine
4) Sucralfate
5) Sodium bicarbonate
6) Misoprostol
7) Helicobacter pylori
8) Nizatidine
9) Omeprazole
10) Tetracycline

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Old 01-25-2013
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5) Sodium bicarbonate
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Old 01-25-2013
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2) Aluminium hydroxide

5) Sodium bicarbonate
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Old 01-25-2013
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can you explain your choices plz.
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Quote:
Originally Posted by Master shifu View Post
2) Aluminium hydroxide

5) Sodium bicarbonate
The answer is Sodium Bicarbonate

It's an antacid which gets absorbed by the mucosa cells in the stomach so that increases the body's pH. I'm not sure about Alumminium hydroxide, I know it causes constipation and its not readily absorbed by the mucosal cells.
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Quote:
Originally Posted by SarahM View Post
Excessive use of which of the following compounds may cause metabolic alkalosis?

1) Pirenzepine
2) Aluminum hydroxide
3) Cimetidine
4) Sucralfate
5) Sodium bicarbonate
6) Misoprostol
7) Helicobacter pylori
8) Nizatidine
9) Omeprazole
10) Tetracycline


Metabolic alkalosis - Increase pH, increase CO2, and increase HCO3-. So the answer is Sodium bicarbonate.
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Old 01-26-2013
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Because the normal kidney is so efficient at excreting HCO3,base loading,whether exogenous or endogenous (as in bone dissolution), is rarely a sole cause of significant sustained metabolic alkalosis. Transient acute metabolic alkalosis commonly occurs during and immediately after oral ingestion or intravenous infusion of NaHCO3. Ingestion of NaHCO3 (baking soda) or a metabolic precursor, such as acetate or citrate, does not produce sustained metabolic alkalosis unless intake is massive.


Nonabsorbable antacids have also been associated with alkalosis when used together with cation-exchange resins in the setting of renal insufficiency.The proposed mechanism is that magnesium or aluminum hydroxides, which normally bind HCl, are bound by the resin in exchange for Na+. Because the sodium carbonates formed are soluble, HCO3 is readily reabsorbed by the intestine and alkalosis ensues because the kidney is unable to excrete the HCO3.
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