CD 117, vimentin , and CD 34! - USMLE Forums
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Old 02-02-2013
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GIT CD 117, vimentin , and CD 34!

She came in with complains of difficult swallowing, fatigue, abdominal discomfort, weight loss, and pale skin seen during PE. Biopsy was done, and in histochemical staining cells was positive for CD 117, vimentin , and CD 34. Whats the MOST possible origin of these cells?

a. epithelial cells
b. parietal cells
c. brunner glandular cells
d. interstitial cajal cells
e. hemapoietic cells
f. metastasis cells

see below endoscope findings, and HE staining of stomach tissues .
Attached Thumbnails
CD 117, vimentin , and CD 34!-2.jpg   CD 117, vimentin , and CD 34!-3.jpg  
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Old 02-02-2013
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I guess is A.
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Old 02-02-2013
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epithelial cells?????...Not sure.
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Old 02-02-2013
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interstitial cells of cajal ....... dx : GIST
cd117 present on ICC, hematopoetic cells etc
images courtesy wikipedia

Last edited by crusader; 02-02-2013 at 02:45 PM. Reason: spell check
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Old 02-02-2013
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Interstitial cell of cajal. CD 117 positive so diagnosis is GIST
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Old 02-03-2013
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Quote:
Originally Posted by crusader View Post
interstitial cells of cajal ....... dx : GIST
cd117 present on ICC, hematopoetic cells etc
images courtesy wikipedia
yar right crusader , addition point are GIST are non epithelial tumors , believd originate from connective tissue and Neural crest (has both properties ) .
mutated gene = kit gene = tyrosine kinase ( so u may link here Rx CTX will be same as CML by imatinib ) .
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