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Old 02-07-2013
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GIT H Pylori and Acid secretion!

Who can explain the mechanism of decreased H secretion in gastric ulcer caused by H. Pylori.

And increased H secretion, caused by Duodenal H. Pylori infection?
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Old 02-07-2013
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H. pylori cause local inflammation of the gastric mucosa which decreases the number of somatostatin-producing antral cells by an unclear mechanism.
- Note: somatostatin is a hormone that inhibits gastrin release. In the absence of somatostatin, high gastrin levels cause increased local release of histasmine which stimulates the gastric parietal cells to secrete increased levels of acid…the resulting very low pH gastric fluid enters the duodenum & if not adequately neutralized by local bicarbonate production, causes duodenal ulceration
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Old 02-07-2013
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Quote:
Originally Posted by luschka View Post
H. pylori cause local inflammation of the gastric mucosa which decreases the number of somatostatin-producing antral cells by an unclear mechanism.
- Note: somatostatin is a hormone that inhibits gastrin release. In the absence of somatostatin, high gastrin levels cause increased local release of histasmine which stimulates the gastric parietal cells to secrete increased levels of acid…the resulting very low pH gastric fluid enters the duodenum & if not adequately neutralized by local bicarbonate production, causes duodenal ulceration

Straight outta UWorld
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Old 02-07-2013
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Quote:
Originally Posted by warfarin90 View Post
Straight outta UWorld
@warfarin90

I know you will do really well on Step because you obviously memorize UWorld word for word. Props!
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