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  #1  
Old 02-08-2013
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Question Chemical Properties of an Antidote!

59 year old man presents to the emergency department because of a rapid heartbeat. ECG shows atrial fibrillation. The physician begins administering a common intravenous anticoagulant as prophylaxis against thrombosis, but the ordered dosage is accidentally tripled. 30 minutes later, a phlebotomist is unable to stop the patientís bleeding after a routine venipuncture. An agent that will reverse the effects of this patientís accidental overdose works because it has which of the following chemical properties?


A) Highly anionic
B) Highly cationic
C) Large and polar
D) Small and nonpolar
E) Zwitterion molecule
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  #2  
Old 02-08-2013
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Good Question.Thanks

Is it Heparin overdose ? and asking for the the chemical properties of protamine ?

My wild guess would be
D.Small and Non polar.
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Old 02-08-2013
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Default HEA

59 year old man presents to the emergency department because of a rapid heartbeat. ECG shows atrial fibrillation. The physician begins administering a common intravenous anticoagulant as prophylaxis against thrombosis, but the ordered dosage is accidentally tripled. 30 minutes later, a phlebotomist is unable to stop the patientís bleeding after a routine venipuncture. An agent that will reverse the effects of this patientís accidental overdose works because it has which of the following chemical properties?



B) Highly cationic peptide

it binds with heparin then forms the complex of protamine+heparin which is finaly removed and broken down by reticuloendothelial system..
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Old 02-08-2013
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Default protamine sulfate

Wow...word by word from FA...."protamine sulfate (positively charged molecule that binds negatively charged heparin)."

another way to say positively charged molecule = cationic...wow.
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Old 02-08-2013
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Not exactly word to word. I will give another 12 hours and then I will reveal the real answer.
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  #6  
Old 02-09-2013
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Correct Answer Correct answer is B

This patient is suffering from Heparin overdose. Overdose of Heparin is treated with Protamine Sulfate. Protamine Sulfate is positively charge; while Heparin is negatively charge. Therefore, Protamine Sulfate is cationic molecule that binds anionic molecule of Heparin and inhibits Heparin's effects.

Warfarin on other hand is small and nonpolar, meaning lipid soluble. Treatment of Warfarin overdose will be Vitamin K and Fresh Frozen Plasma. If patient is in nonbleeding asymptomic state then Vitamin K is right choice. If patient is bleeding/symptomic state then Fresh Frozon Plasma is the right choice.

Another name for Vitamin K is Phytonadione. Vitamin K is nonpolar, fat lipid.

Last edited by Doctor Ali; 02-09-2013 at 08:42 AM.
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