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Edema Pathophysiology

5K views 23 replies 7 participants last post by  neha_subh 
#1 · (Edited)
Physical examination reveals symmetrical pitting edema of ankles, which of the following most likely decrease in this patient??

1) plasma oncotic pressure
2) tissue lymphatic drainage
3) circulating aldosterone level
4) capillary hydrostatic pressure

i know its easy question not difficult but after your's response i will ask another question which is related to this question, first give me answer of this question
 
#8 ·
ya..nephrotic syndrome or liver cirrhosis. Just to get the general idea that protein low --> transudate (pitting edema)

But I guess in either case, renin (and thus aldosterone) would increase because fluid would move out of the blood vessel.

In heart failure, renin would increase due to low renal perfusion.

Hope i have the concept right :rolleyes:
 
#10 · (Edited)
Physical examination reveals symetrical piting edema of ankles,which of the folowing most likely decrease in this patient??

1) plasma oncotic presure
2)tisue lymphatic drainage
3)circulating aldosterone level
4)capilary hydrostatic presure

i know its easy question not dificuilt but after your's response i wil ask another question which is related to this question, first give me answer of this question
There will be decrease plasma oncotic pressure due to the fact that there's decrease albumin. Sounds like Nephrotic syndrome to me.;)

Next, what about aldostrone level?

Well, here's how I would think about it. Besides Nephrotic syndrome, what else causes edema? How about Right sided heart failure? What causes Right Sided heart failure? How about Left sided heart failure? Now put Left sided heart failure + Right sided heart failure together and you now have Congestive heart failure.

Next, what happens in CHF?

1. Decrease Blood Pressure
2. Decrease Renal perfusion pressure

Then what happens?

1. Increase sympathetic nerves
2. Increase Renin secretion - which increase aldosterone

So in Edema there is:

1. Decreased plasma oncotic pressure
2. Increased aldosterone

In other way of looking at it, Nephrotic syndrome belongs to Transudate. What else belongs in this group of Transudate? How about CHF?Happy-2

A friend of mine told me the difference between Exudate and Transudate when I asked. Remember?:p:p:p
 
#11 ·
nephrotic syndrome:

Physical examination reveals symmetrical pitting edema of ankles, which of the following most likely decrease in this patient??

1) plasma oncotic pressure------decrease (hypoalbuminemia)
2) tissue lymphatic drainage-----increased (bc fluid is acumulated in intrstitium it must be drained particularly in this patient)
3) circulating aldosterone level--increased (bc decrease intravascular volume due to leakage into intrstitium-- compnsatory increase aldosterone--fluid retention)
4) capillary hydrostatic pressure--increased..

this patient has nephrotic syndrome..
 
#12 ·
we really need threads like this one..

hello everybody :) this is my first post..

I really think we need more of such posts discussing multi step questions and testing our understanding randomly..

Cud we make this thread the mother thread of such useful stuff??
To let anybody ask confusions, share amazing mechanisms/links/logics between topics etc..?
 
#13 ·
pahtophysio quesiton pool:

hello everybody :) this is my first post..

I really think we need more of such posts discussing multi step questions and testing our understanding randomly..

Cud we make this thread the mother thread of such useful stuff??
To let anybody ask confusions, share amazing mechanisms/links/logics between topics etc..?
dont ask you can...
put questions in this pool (easy+ dificult)
 
#14 ·
Acid Base disorder:

High altitude exposure lasting more than few days (5days),ABG's value would be most expected in this patient???

-- PH -- PaO2 -- PaCO2 -- HCO3

a) 7.48 -- 60 -- 20 -- 15

b) 7.50 --96-- 30-- 17

c) 7.57 -- 75 -- 50 -- 32
 
#16 ·
High altitude exposure lasting more than few days (5days),ABG's value would be most expected in this patient???

-- PH -- PaO2 -- PaCO2 -- HCO3

a) 7.48 -- 60 -- 20 -- 15

b) 7.50 --96-- 30-- 17

c) 7.57 -- 75 -- 50 -- 32
mine next question is: in emphysema alveolar spaces dilated then whats the reason behind air flow obstruction??
if any one have lil bit concept about it so pls share with us
 
#19 ·
High altitude exposure lasting more than few days (5days),ABG's value would be most expected in this patient???

-- PH -- PaO2 -- PaCO2 -- HCO3

a) 7.48 -- 60 -- 20 -- 15 (answer)

b) 7.50 --96-- 30-- 17

c) 7.57 -- 75 -- 50 -- 32
 
#23 ·
Allocation bias:

please tell me lil bit about alocation bias it results from the way that treatment and controled groups are assembled i cant understand its theory,when i see bias i get worse headache what should i do with them because these bias dont cros mine brain bariers easily i tried alot to improve biostatics but these bias wil take mine life one day esp on exam day :toosad:
 
#24 ·
alocation bias:

alocation bias it results from the way that treatment and controled groups are assembled :toosad:
got this explanation(from wikipedia):
it may ocur if subjects are assigned to study group of clinical trial in a non random fashion.
here is example: in a study group oral NSAIDs and intra articular corticosteroids injections for the treatment of the osteoarthritis,obese patient may be preferentialy assigned to the corticosteroids group.
 
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