Systemic Sclerosis and another question - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 09-18-2010
USMLE Forums Addict
 
Steps History: Not yet
Posts: 161
Threads: 60
Thanked 24 Times in 20 Posts
Reputation: 34
Send a message via Skype™ to Androide89
Question Systemic Sclerosis and another question

In systemic sclerosis what are the cells responsible for the sclerosis of the dermis/arterioles. I remember the choices had down endothelium, platelets, lymphocytes, neutrophils. I was looking for fibroblasts but that wasn't a choice. any idea??

Also what bacteria is transmitted via a tick bite in Grand Canyon area? that stains with wright's?
Reply With Quote Quick reply to this message



  #2  
Old 09-18-2010
USMLE Forums Guru
 
Steps History: ---
Posts: 487
Threads: 69
Thanked 297 Times in 134 Posts
Reputation: 317
Default

event is initiated by endothelial injury....but actual fibrosis is caused by lymphocytes....

Fibrosis can be caused by profibrotic cytokines, including transforming growth factor-beta (TGF-beta), interleukin-4 (IL-4), platelet-derived growth factor (PDGF), and connective-tissue growth factor.1 The vasculopathy may be linked to TGF-beta and PDGF, while the diminution of lesional cutaneous blood vessels can be attributed to antiendothelial cell autoantibodies. The activation of the immune system is of paramount importance in the pathogenesis of systemic sclerosis. Antigen-activated T cells, activated infiltrate early, infiltrate the skin, and produce the profibrotic cytokine IL-4. B cells may contribute to fibrosis, as deficiency of CD19, a B-cell transduction molecule, results in decreased fibrosis in animal models.

source eMedicine....
__________________
258(1)/237(1)/CS pass(1)/YOG 2011/221(1)/6 months USCE/ 3 months observership/4 US LOR /Need visa
To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.
Reply With Quote Quick reply to this message
The above post was thanked by:
Androide89 (09-18-2010), lee-usmle (09-19-2010), Sabio (09-19-2010)
  #3  
Old 09-18-2010
USMLE Forums Guru
 
Steps History: ---
Posts: 487
Threads: 69
Thanked 297 Times in 134 Posts
Reputation: 317
Default

bacteria is transmited via a tick bite in Grand Canyon area? that stains with wright's?.....i think its borrelia burgdorferi....
__________________
258(1)/237(1)/CS pass(1)/YOG 2011/221(1)/6 months USCE/ 3 months observership/4 US LOR /Need visa
To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.
Reply With Quote Quick reply to this message
 
  #4  
Old 09-18-2010
USMLE Forums Addict
 
Steps History: Not yet
Posts: 161
Threads: 60
Thanked 24 Times in 20 Posts
Reputation: 34
Send a message via Skype™ to Androide89
Default

thanks! yeah i guess it must be b.burgdoferi
Reply With Quote Quick reply to this message



Reply

Tags
Microbiology-, Pathology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Tuberous Sclerosis Sabio USMLE Step 1 Mnemonics 0 08-26-2009 09:14 PM
Nodular Sclerosis StepTaker USMLE Step 1 Bits & Pieces 0 08-05-2009 05:07 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)