Dorsal Root Ganglion Relational Neuroanatomy - USMLE Forums
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Old 02-10-2013
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Question Dorsal Root Ganglion Relational Neuroanatomy

A 35-year-old man has a knife wound to the neck that completely destroys the len C6 dorsal root ganglion. Two months later, the
axons, dendrites, and nerve cell bodies of this damaged structure have completely degenerated, but there is no other damage.
Which of the following changes in the spinal cord will most likely be produced as a result of this injury?
0 A. Axonal loss in the contralateral spinothalamic tract
0 B. Axonal loss in the ipsilateral dorsal columns
0 C. Axonal loss in the ipsilateral lateral corticospinal tract
0 D. Nerve cell body loss in the contralateral ventral horn
0 E. Nerve cell body loss in the ipsilateral dorsal horn

i did e, its WRONG ! i dont know why . please help ...
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  #2  
Old 02-10-2013
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its B review ur neuroanatomy.
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Old 02-11-2013
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I will go for E
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Old 02-11-2013
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that question i answered was not based on axon or cell body damage it was based on the location of lesion .... it was at the dorsal root ganglion. and from the dorsal root ganglion axons ascend in the posterior (dorsal column) within the gracilis and cuneatus and ascend in the medial leminiscus through the internal arcuate fibres.

Regarding your question about axonal loss and cell body loss, Axon loss is degeneration of the axon usually followed by myelin degeneration as well as macrophage infiltration. I t can be seen in diseases such as. Multiple sclerosis and Gulliane barre.

the nerve cell bodies coontaining cytoplasm and nuclei are usually damaged in lesions of nuclei containing the cell bodies. e.g facial nuclei lesion, nucleus solitarius, dorsal motor nucleus etc..

hope that helps
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Old 02-11-2013
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just to clarify. Would axonal loss in ipsilateral spinothalamic tract be a correct choice?
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Old 02-11-2013
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Quote:
Originally Posted by django View Post
just to clarify. Would axonal loss in ipsilateral spinothalamic tract be a correct choice?
NO it won't
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Old 05-13-2013
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most probably b, acc to wallerian and anterograde rule of degeneration fotrsensory tracts the afferents for dorsal column are blocked so they can undergo degeneration.
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