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  #1  
Old 02-11-2013
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Drug Argatroban for HIT

"Argatroban is an antithrombotic drug largely used in the treatment of heparin induced thrombocytopenia. argatroban is a direct thrombin inhibitor"

okay so why are we using an antithrombotic drug(argatroban) to treat the side effects(thrombocytopenia) of another antithrombotic drug(heparin)?

aren't we going to accomplish the same results?
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Old 02-11-2013
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It's not used to treat the side effect persay. it's used to provide anticoagulation in patients with strongly suspected or proven HIT, danaparoid, lepirudin, and argatroban. These are "alternatives" to heparin therapy.

Secondly anti-thrombic drugs inhibit "coagulation factors" note that this doesn't have anything to do with the platelet count. its only heparin that has the SE of thrombocytopenia.
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Old 02-11-2013
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Quote:
Originally Posted by obinocle View Post
It's not used to treat the side effect persay. it's used to provide anticoagulation in patients with strongly suspected or proven HIT, danaparoid, lepirudin, and argatroban. These are "alternatives" to heparin therapy.

Secondly anti-thrombic drugs inhibit "coagulation factors" note that this doesn't have anything to do with the platelet count. its only heparin that has the SE of thrombocytopenia.
How would anticoagulation therapy(argatroban) benefit someone with thrombocytopenia?

I idea in my mind is that platelets are involved with coagulation. Therefore anticoagulants-> decrease platelets eventually and Coagulation->platelets doing their job
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Old 02-11-2013
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Quote:
Originally Posted by ballers View Post
How would anticoagulation therapy(argatroban) benefit someone with thrombocytopenia?

I idea in my mind is that platelets are involved with coagulation. Therefore anticoagulants-> decrease platelets eventually and Coagulation->platelets doing their job
Isn't the goal in a patient with thrombocytopenia(low platelets) to prevent the thrombocytopenia? Why give anticoagulants?
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Old 02-11-2013
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Quote:
Originally Posted by ballers View Post
Isn't the goal in a patient with thrombocytopenia(low platelets) to prevent the thrombocytopenia? Why give anticoagulants?
the goal in tx patients with thrombocytopenia is to stop the drug causing the effect and allow the body to replenish platelets.... those other drugs are given just as alternatives so that the patient does not have another episode.
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Old 02-11-2013
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Quote:
Originally Posted by ballers View Post
How would anticoagulation therapy(argatroban) benefit someone with thrombocytopenia?

I idea in my mind is that platelets are involved with coagulation. Therefore anticoagulants-> decrease platelets eventually and Coagulation->platelets doing their job
You are wrong about this. that is what i told you in the previous post... yea platelets may play a part in coagulation but they are not the major effectors. It is the coagulation factors e.g factor 2,7,9,10, thrombin et.c that play the major roles and this is what the anticoagulants inhibit. they do not inhibit platelets !!!. Heparin is the odd man out because he inhibits platelets as well which is not a major goal in anticoagulation therapy. it is infact a side effect becuse platelets are required for other important functions other than coagulation.
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Old 02-11-2013
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okay so check this.

Argatobran is used as an alternative to heparin for the purpose of inhibiting coagulation factors . However the advantage of argatobran is that you won't get a low platelet count, as you would with heparin therapy. Is this correct?
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Quote:
Originally Posted by ballers View Post
okay so check this.

Argatobran is used as an alternative to heparin for the purpose of inhibiting coagulation factors . However the advantage of argatobran is that you won't get a low platelet count, as you would with heparin therapy. Is this correct?
perfecto!!!!
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Old 02-15-2013
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I read in uworld explaination that "in heparin induced thrombocytopenia, thrombosis, not bleeding, is a risk" HIT causes thrombosis instead of bleeding paradoxically. Hence the use of Argatroban to prevent thrombosis.
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