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Old 02-12-2013
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Question PCOS Hormonal Profile?

From my understanding in PCOS you will see the following:

decrease LH,
increase androgen
increase estrone
decrease FSH
decrease estradiol

is this correct?
also why do you get increase in androgen: is it because LH stimulates the theca cells to produce excess androstenedione which then gets converted to testosterone? Please explain
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Old 02-12-2013
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inc LH, testosterone, estrogen
dec FSH
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Old 02-12-2013
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regarding estrogen:
there is increase in estrone and decrease in estradiol, correct? I believe the increased androgen causes increased estrone production which inturn causes negative feedback to decrease FSH, hence decrease in estradiol
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Old 02-13-2013
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Quote:
Originally Posted by DOCSHO View Post
regarding estrogen:
there is increase in estrone and decrease in estradiol, correct? I believe the increased androgen causes increased estrone production which inturn causes negative feedback to decrease FSH, hence decrease in estradiol
Yes, increase estrone & decrease estradiol.

Increased LH hits the theca cells & induces excess androgen production. Androgens will go into the blood will lead to resulting in hirsutism (excess hair in a male distribution; heavy facial hair. Androgens also go into adipose tissue & the androgens will convert to estrone (recall that estrone is the estrogen made from adipose tissue). The excess estrone will go back to the pituitary & feedback & shut down production of FSH. A low FSH will not allow granulosa cells to do its job. So, the granulosa cells will not be able to convert androgens into estradiol, thus a decrease in estradiol.

Subsequently, there will be a degeneration of this follicles bc they’re not able to produce the estrogen necessary to be able to maintain the follicle. The follicle will degenerate & become cystic…also…high levels of circulating estrone increase risk for endometrial carcinoma (recall that the risk for endometrial carcinoma is an increase exposure of estrogen) will lead to polycystic ovarian syndrome.
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Quote:
Originally Posted by luschka View Post
Yes, increase estrone & decrease estradiol.

Increased LH hits the theca cells & induces excess androgen production. Androgens will go into the blood will lead to resulting in hirsutism (excess hair in a male distribution; heavy facial hair. Androgens also go into adipose tissue & the androgens will convert to estrone (recall that estrone is the estrogen made from adipose tissue). The excess estrone will go back to the pituitary & feedback & shut down production of FSH. A low FSH will not allow granulosa cells to do its job. So, the granulosa cells will not be able to convert androgens into estradiol, thus a decrease in estradiol.

Subsequently, there will be a degeneration of this follicles bc they’re not able to produce the estrogen necessary to be able to maintain the follicle. The follicle will degenerate & become cystic…also…high levels of circulating estrone increase risk for endometrial carcinoma (recall that the risk for endometrial carcinoma is an increase exposure of estrogen) will lead to polycystic ovarian syndrome.

awesome!!, thanks for the detailed explanation.
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