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Old 09-19-2009
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Question Tay Sachs and Niemann Pick

Hey,

How to tell them apart?

They both common in Ashkenazi Jews
They both cause Cherry red spot
They both cause blindness
They both kill early in life
They both cause mental retardation
They both cause seizures
They both are autosomal recessive
They both are lysosomal storage disorders

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Old 09-19-2009
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Nieman pick has reticuloendothelial system involvement
No Nieman pick child comes to the hospital without huge liver and spleen

Also in Nieman pick you have the cytoplasmic vacuolation and the bone marrow involvement

All these are not seen in Tay Sach
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Old 09-27-2009
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OK but then we'll mix up Nieman with Gaucher, again seen in Ashkenazi Jews!
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Old 09-27-2009
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Quote:
Originally Posted by In-N-Out View Post
OK but then we'll mix up Nieman with Gaucher, again seen in Ashkenazi Jews!
Only type I (the adult type) of Gaucher is seen in Ashkenazi Jews. This type is far more compatible with life and children may live to the second decade of their life, while in Nieman pick they usually die before the second birthday.

The other types of Gaucher (the infantile and the juvenile) are as killing as Niemman but they are not seen in Ashkenazi Jews

In any case Gaucher does not affect the eyes with cherry red spots
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Old 01-22-2011
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Default some more differences

Tac sachs has no hepatospleenomagaly,
lysosome with onion skin , mostly in jews of eastern europeon descent

NiemnnPick has hepatospleenomagaly,
zebra body inclusion and cytoplasmic vacolization (foam cells) present
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