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  #1  
Old 03-07-2013
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Drug Statins Effects on Hepatocytes!

I found this question in FA Q&A and its answer make me so confuse!

HMG CoA reductase inhibitor (statins) are the most effective drugs available for reducing LDL levels. Statins cause several downstream effects by inhibiting the rate-limiting step in hepatic cholesterol synthesis. What is the primary effect of statins on hepatocyte
A. Decrease hepatic production of LDL
B. Decrease production of triglycerides
C. Downregulation of cell surface LDL receptors
D. Increase production of HDL
E. Upregulation of cell surface LDL receptors


I think A but it ans E ,, Why?
Anybody Help pls
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Old 03-07-2013
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LDL is not synthesized in liver. Liver produces VLDL which is released. It breaks into IDL which acquire cholesterol from HDL to form LDL. Hence option A is wrong.
Statins decrease hepatocyte cholesterol synthesis. Decreased cholesterol causes upregulation of LDL receptors to increase LDL uptake. Hence option E is the right choice.
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  #3  
Old 03-07-2013
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probably u mixed up the formation of cholesterol with formation of LDL

LDL synthesis continues as it depends on hepatic TG lipase from IDL (which is the byproduct of VLDL degradation)

statins inhibit cholesterol synthesis that causes upregulation of LDL receptors which are the source of cholesterol
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Old 03-08-2013
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i will go with E
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Old 08-22-2013
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Quote:
Originally Posted by alexmittal View Post
How well do you know cholesterol subject?

I think it's E!

Just want to share something, the other day my friend made a statement that he knows nothing about cholesterol even though the doctor told him that his cholesterol level is through the roof. Can you recommend some websites that are reliable when it comes to cholesterol data ?
Mayo clinic website may have some good info, or medscape
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Old 09-19-2013
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statins inhibit HMG COA reducatse thereby decrease cholesterol synthesis. decreased cholesterol upregulates LDL receptor level-kaplan biochem page 231
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Old 09-20-2013
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i got this question wrong in U world a couple of times, but i know the right answer now . Its E. Statins upregulate LDL receptor production. As we know, the main effect of statins is the decrease of LDL. Statins decrease cholesterol production through inhibition of HMG-CoA to mevalonate. This in turn, causes upregulation of LDL receptors in order to allow LDL uptake from the circulation.
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