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Old 03-11-2013
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Default Heparin mechanism

I thought that heparin moa is to enhance the action of ATIII which then decreases thrombin and Xa. But I got the nbme question wrong. Am I missing something? Sorry if this is a stupid question =)
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Old 03-11-2013
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Edit :

Heparin binds to the enzyme inhibitor antithrombin III (AT) causing a conformational change that results in its activation through an increase in the flexibility of its reactive site loop.[15] The activated AT then inactivates thrombin and other proteases involved in blood clotting, most notably factor Xa. The rate of inactivation of these proteases by AT can increase by up to 1000-fold due to the binding of heparin.[16]

http://en.wikipedia.org/wiki/Heparin...nism_of_action
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Old 03-11-2013
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yeah, Heparin is a cofactor for Antithrombin III
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Heparin activates Antithrombin which inhibits thrombin hence no clotting.
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