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  #1  
Old 03-11-2013
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Default *NBME question

A 5 lb 8 oz female newborn is delivered to a woman who had no prenatal care. PE of baby shows jaundice, nasal flaring, and grunting. Labs show anemia + hyperbilirubinemia. Newborn is blood group O, Rh +, and the mother is blood group O, Rh -. Which of the following most likely mediated the transplacental transfer of the maternal factor causing this newborn’s Sx?

A. C3b
B. Fc Receptor
C. IL-2
D. a/b T-lymphocyte Receptor
E. Transferrin receptor


Please provide reasoning for your answer. Thanks.
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Old 03-11-2013
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B. Fc Receptors.

The questions is actually asking IgG will attach to which receptors? IgG crosses placenta.And it attaches Fc receptors.

I think this also applies to rheumatoid arthritis.(Not sure though).
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Old 03-11-2013
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Wording is so poor. I know the concept but wording got me. Thanks.
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Old 03-11-2013
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Quote:
Originally Posted by warfarin90 View Post
Wording is so poor. I know the concept but wording got me. Thanks.

You are right...80 % of the questions I get wrong on NBMEs are either of the wording or I don't know the simple definitions.

I got this one wrong as well but later checked it.Hopefully won't forget it again.
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Old 03-11-2013
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Same here. When are you taking the exam?
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Old 03-11-2013
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March 21st...when is yours?

I am damn nervous...too much on stake.
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Old 03-11-2013
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a month from now. same here I'm saving nbme 7 and 13 for the last 2 weeks.
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Old 01-16-2014
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Quote:
Originally Posted by warfarin90 View Post
a month from now. same here I'm saving nbme 7 and 13 for the last 2 weeks.
hey guys! for this question..why can't it be c3b that also is related to IgG since IgG activates compliments..
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Old 01-16-2014
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Wink

your way of thinking is correct but here they are asking which crossed the transplacental barrier and the most likely to cross it is IgG, hope i cleared your question, good luck
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  #10  
Old 01-16-2014
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Quote:
Originally Posted by drpisho View Post
your way of thinking is correct but here they are asking which crossed the transplacental barrier and the most likely to cross it is IgG, hope i cleared your question, good luck
hey thanks Interferon wannabe got it..
Since you're good at ur immuno maybe u can help me with this..I don't understand what the q is asking here and why the ans is IL 1? they want to PREVENT so something that inhibits inflammation..IL1 is increased in inflammation..plz and thank you!

In order to investigate possible tx options for ARDS, experimental animals are anesthetized and subjected to smoke inhalation (cotton smoke) according to well established experimetnal protocol. Experimental animals are given compounds designed to upregulate specific mediators involed in inflammatory cascade. Upregulation of which mediator would most likely prevent or amelilorate lung injury induced in this experimental model of ARDS?

a. IL 1
b. IL 10
c. NFKB
d. Toll like receptors
e. TNF
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Old 02-02-2014
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For the transplacental transfer question: You know its IgG is the cause of Hemolytic disease of newborn but it asks which of the following mediated the transfer of it. So its the Fc portion of the IgG that bound to the Fc receptor that allowed its transfer. Turns out the wording was perfectly normal. read the source: http://www.ncbi.nlm.nih.gov/pubmed/8766556
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