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Old 03-14-2013
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Default On FirstAid under Biochem section...

I was wondering if anyone can help me with something that I don't understand. I'm using first aid 2012, there is this section under Biochemistry, about "Glycolysis regulation, key enzymes" on page 104.
I don't' understand what the negative and positive sign mean next to ATP -, Glucose 6 P - hexokinase, Fructose 6 P - glucokinase.

Can anyone explain me please?

Thank you
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Old 03-14-2013
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Originally Posted by ladydoc0208 View Post
I was wondering if anyone can help me with something that I don't understand. I'm using first aid 2012, there is this section under Biochemistry, about "Glycolysis regulation, key enzymes" on page 104.
I don't' understand what the negative and positive sign mean next to ATP -, Glucose 6 P - hexokinase, Fructose 6 P - glucokinase.

Can anyone explain me please?

Thank you
+ = activation and - = inactivation of key enzymes involved in the cycle:

1. glucose ---- glucose 6 phosphate, the key enzyme is hexokinase and glucokinase . So Glucose-6-phosphate which is the product of this reaction tends to stop the reaction for further continuation of its production by inhibiting hexokinase.

2.Fructose-6-P----Fructose-1,6-BP . Here the key enzyme is phosphofructokinase-1 and this enzyme is inhibited by ATP and Citrate and Activated by AMP and fructose -2,6-BP.

Same goes for the remaining two reactions given in the first aid. Main thing is to know what factors induce or inhibit the key enzymes in the cycle.
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