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Old 09-29-2010
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Unhappy Basic cell physiology/pathology

I'm having trouble with stuff like metalloproteinases, caspases, PDGF, IGF...

I can't find such stuff in FA nor in Kaplan!! I'm not able to categorize them; are they under pathology or physiology?

Where can I find a good source about them?
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Old 09-29-2010
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Quote:
Originally Posted by Haisook View Post
I'm having trouble with stuff like metalloproteinases, caspases, PDGF, IGF...

I can't find such stuff in FA nor in Kaplan!! I'm not able to categorize them; are they under pathology or physiology?

Where can I find a good source about them?
The important thing about caspases is that they will be involve in cell death induced by cell injury or because of apoptosis, they are activated by calcium influx in the cell, this is due to the increase permeability because of the membrane damage in the case of cell injury or simply by activation via intrinsic or extrinsic pathways in apoptosis, check this pathways in FA, page 216.

IGF.1 is activated by GH, and is going to be involve in growth, it makes proteins. Is a reflector of 24h secretion of GH. IGF1 has a long life because is bound to protein.
Something important is that IGF1 stimulates somatostatin, wich in turn inhibits GH secretion.
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Old 09-29-2010
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Well, the ideal source if you're really confused is actually the first few chapters of Robbins, but that detail was for med school and not for now... If you really feel your base is weak on this, then you should look over that. However, the material in the USMLEWorld questions should be enough through the various explanations they have. If you're confused after reading the UW explanations I'd then look at Robbins
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Old 09-30-2010
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I did my general path from Robbins first and then goljan and his audio, but most of this stuff that you want to know are from Immuno and Physio, they're just mentioned in mechanisms and pathogenesis in pathology and in Goljan....

if you want a further good understanding i recommend looking into this website, its FREE and the guy does a good job of going over Robbins w/ ppt slides and has a lot of useful Histopathology on there also.

www.medicalschoolpathology.com

hope this helps, Cheers!
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Old 09-30-2010
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So, if I get Goljan RR, will there be certain individual chapters that cover this? And if yes, what are they?
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First off, don't get me wrong, but Goljan only has the ESSENTIAL need to know information which means ONLY a review....so its not going to give you the "in depth" comprehension if that is what you're looking for. All of these are "mentioned" as a part of a pathological pathway. Most of this "kind" of stuff you will find in Endo (physio, path) and immunology itself (and immunological diseases in path) some of them are even mentioned in Genetic and developmental disorders (both of which are very imp supposedly, I heard 2 of my friends get a LOT of crazy questions in genetics and immuno). That being said, the book is superbly written for MOST of the need to know information.

Though I don't exactly remember where all of these things are in Goljan, I mean like exact page numbers but I gave you a general outline of where you should look for them (most of them are in the first few chapters like 1-3, 5, 22 these are also the topics that I mentioned above). The exact 1's that you asked for are in the first 3 chapters I believe. Here's what I remember of what they are pertaining to in Goljan

1) Caspases you will find in apoptosis
2) Metalloproteinases (collagenases and others) in wound healing
3) IGF-1 pertaining to collagen synthesis, and PDGF stimulates proliferation of endothelial cells (smooth muscle) and fibroblasts (I think...lol) but both of them pertain to tissue repair!

now most things like these are in chart form in goljan but if you cover the topics that I told you at the beginning you will easily integrate everything and should have a better understanding of what, why, where and how!

good luck, hope this helps!
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