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Old 03-18-2013
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Question Nephrogenic Diabetes Insipidus Treatment

Can someone please explain the mechanism of action of the drugs used to treat NEPHROGENIC diabetes insipidus, which are mainly Hydrochlorothiazide, Indomethacin, or Amiloride. How do these drugs help in nephrogenic DI
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Old 03-18-2013
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Hydrochloro and Indomethacin - I can't recall.

Amiloride is the treatment you give for Lithium toxicity. Doing this, will inhibit lithium's action on the kidney - which originally blocks the ADH receptors. Treating the lithium toxicity/overdose will allow the adh receptors to free up, and bind to the receptors and allow for the action to take place.
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Old 03-19-2013
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So why treat excess diuresis with diuretics?

Thiazides will decrease water reabsorption in distal convuluted tubule, which will cause a COMPENSATORY increase in sodium and water reabsorption in the proximal tubule, leading to a net decrease in diuresis.

http://ndt.oxfordjournals.org/content/15/12/1903.long
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Old 03-19-2013
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Read this explanation
Treatment for nephrogenic diabetes insipidus?

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Pharmacology-, Physiology-, Renal-

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