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  #1  
Old 03-19-2013
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Immunology Inflammatory Cells in anti-Scl 70 Positive Disease

A 45-year-old woman comes to the physician because of a 6-month history of mouth ulcers, thickening of the skin, and throbbing pain in her hands when they are exposed to the cold. She also has had a 1-month history of severe headaches and difficulty swallowing. Physical examination shows small red lesions around the mouth and generalized muscle weakness. Laboratory studies show a high titer of anti-Scl 70 (anti-topoisomerase I) antibody. A biopsy specimen of the skin shows thinning of the epidermis, hyalinization and obliteration of arterioles, and dermal thickening. These dermatologic changes are caused primarily by the release of chemokines from which of the following inflammatory cell types?

A ) Endothelial cells
B ) Eosinophils
C ) Lymphocytes
D ) Mast cells
E ) Platelets
F ) Segmented neutrophils
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Old 03-19-2013
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Lymphocytes.
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  #3  
Old 03-20-2013
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this is CREST syndrome

I'm guessing C) Lymphocytes (T cells)
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Old 03-20-2013
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Is it Lymphocytes? and what could be the cytokines that lead to this phenomenon?
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Old 03-21-2013
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this looks like Scleroderma, and T cell release of chemokines seems to fit.
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Old 03-21-2013
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will go with lymphocytes ,cells of chronic inflammation
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Old 03-22-2013
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i m btw a and c
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Old 03-23-2013
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not sure but I will go with Lymphocytes
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