Bruton's agamma vs SCID clinical presentation - USMLE Forums
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Old 03-22-2013
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Immunology Bruton's agamma vs SCID clinical presentation

Hey all. Can someone tell me the difference in clinical presentation for the above two? Both are young children + both show failure to thrive + both cause recurrent infections
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Old 03-22-2013
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Usually, the Bruton's child will present with recurrent bacterial infections.
Whereas the child with scid has a much more severe immune deficiency, so they can get everything from viruses, fungi, bacteria and protozoa. You'll see organisms that you'd expect to see only in AIDS patients in scid.
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Old 04-07-2013
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Something else to add:

Bruton's agammaglobulinemia thymic shadow is intact because it is just a B cell disorder.
With SCID thymic shadow is absent because there is no T cells.

In FA 2012 page 237 you can find that with Bruton's Agammaglobulinemia there is an absence of the thymic shadow but this is a mistake they corrected in the errata, so don't get confused.
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