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Old 03-24-2013
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Drug Seizure Drug of Choice; Petit Mal and Pregnancy

Q1. DOC for Petit mal seizures-
Q2. DOC for epilepsy in pregnancy-

1. Valproate
2. Ethosuximide
3. carbamazepine
4. phenytoin
5. Phenobarbitone


Please reply with reasons - Its confusing as differenttexts say different and am not able to choose the best answer. So need help!!
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1. ethosuximide

2. phenobarbitone
valproate + carbamazepine + phenytoin = teratogenic
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Originally Posted by MedicalExaminer View Post
1.ethosuximide

2.phenobarbitone
valproate + carbamazepine + phenytoin = teratogenic
thats what i thought!!
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Originally Posted by drdhruv View Post
thats what i thought!!
that was given as such in FA but errata removed it as first line treatment

better to use other agents

http://www.ncbi.nlm.nih.gov/m/pubmed/22551726/
still it is associated with risks
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Originally Posted by MedicalExaminer View Post
that was given as such in FA but errata removed it as first line treatment

better to use other agents

http://www.ncbi.nlm.nih.gov/m/pubmed/22551726/
still it is associated with risks
For pregnancy, how about carbamazepine. Some books say it has lower teratogenic effects than pheno.
And the answer for this question in many books is cmz.

Any comment?
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For pregnancy, how about carbamazepine. Some books say it has lower teratogenic effects than pheno.
And the answer for this question in many books is cmz.

Any comment?
what i know from pharm is carbamazepine causes both neural tube defects and cleft lip + palate so theoreticaly it is more teratogenic than phenytoin and valproic acid
but what is its effect from population studies im not able to answer
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Actually that was confusing me too caz I think I studied carbamezapine is safest in pregnancy but in FA its phenobarb and I think it makes sense since carbamazepine is associated with folic acid deficiency so I will pick phenobarb
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I searched in obg books and it says phenobarbital hence I guess it shd be that.
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