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Old 03-25-2013
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Drug Anticholinergic for acute dystonia

Can someone explain the reasoning behind giving benztropine (anticholinergic) to a schizophrenic patient suffering from acute dystonia after taking his antipsychotic?

If you give someone a dopamine antagonist (antipsychotic), how would that increase movement (dystonia) instead of decrease movement?
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Old 03-25-2013
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Schizophrenia is increase Dopamine. So we give a dopamine antagonist for this. Now we encounter side effect - acute dystonia. Acute dystonia happens in 4 hrs.

Next, there is a STRONG BALANCE RELATIONSHIP between Dopamine and ACh. So as you decrease Dopamine, ACh automatically increases. This increase ACh causes movements like dystonia. This is why give Benztropine in this case.
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