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Old 03-28-2013
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Drug Calculating Drug Volume of Distribution

A study done to assess properties of new drug in phase 1 trial with t1/2: is 10hrs and clearance of drug is 4L/hour, what will be the best estimate of volume of distribution (vd) of this drug??

a) 6L
B) 14L
C) 60L
D) 90L
E) 45L
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Old 03-28-2013
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C) 60L

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Old 03-28-2013
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t 1/2 = 07 X Vd / CL

Vd = t 1/2 X CL / 0.7

= 10 hrs X 4 L/hr / 0.7

= 57 L

Vd = 57

So, C ~ 60L is correct answer.
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Default corect answer:

corect answer is C:

C)60L

t 1/2 =0.7xvd / cL

vd= t 1/2 x cL / 0.7

10 x 4 / 0.7 = 57 L

57 ~ 60 L

VD=60L
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Old 03-29-2013
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T1/2 = 0.7 x Vd / CL

Vd = t1/2 x CL /0.7

60L is the ans
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