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#1
03-28-2013
 USMLE Forums Veteran Steps History: 1 + CS Posts: 209 Threads: 18 Thanked 112 Times in 75 Posts Reputation: 122
Calculating Drug Volume of Distribution

A study done to assess properties of new drug in phase 1 trial with t1/2: is 10hrs and clearance of drug is 4L/hour, what will be the best estimate of volume of distribution (vd) of this drug??

a) 6L
B) 14L
C) 60L
D) 90L
E) 45L
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#2
03-28-2013
 USMLE Forums Master Steps History: 1+CK+CS+3 Posts: 824 Threads: 66 Thanked 465 Times in 298 Posts Reputation: 475

C) 60L

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 The above post was thanked by: neha_subh (03-28-2013)
#3
03-28-2013
 USMLE Forums Veteran Steps History: Step 1 Only Posts: 283 Threads: 35 Thanked 206 Times in 115 Posts Reputation: 216

t 1/2 = 07 X Vd / CL

Vd = t 1/2 X CL / 0.7

= 10 hrs X 4 L/hr / 0.7

= 57 L

Vd = 57

So, C ~ 60L is correct answer.
 The above post was thanked by: neha_subh (03-28-2013)

#4
03-28-2013
 USMLE Forums Veteran Steps History: 1 + CS Posts: 209 Threads: 18 Thanked 112 Times in 75 Posts Reputation: 122

C)60L

t 1/2 =0.7xvd / cL

vd= t 1/2 x cL / 0.7

10 x 4 / 0.7 = 57 L

57 ~ 60 L

VD=60L
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#5
03-29-2013
 USMLE Forums Newbie Steps History: Not yet Posts: 2 Threads: 0 Thanked 3 Times in 2 Posts Reputation: 13

T1/2 = 0.7 x Vd / CL

Vd = t1/2 x CL /0.7

60L is the ans
 The above post was thanked by: neha_subh (03-30-2013)

 Tags Pharmacology-, Step-1-Questions

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