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#1




Calculating Drug Clearance
If dose is about 3000 ug/day, plasma concentration (Cp) is 15 ug/L then what will be the clearance?
a) 200 L/day b) 45000 L/DAY c) 0.005 L/day
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#2




CL = Maintenace dose / Cp
= 3000 ug/day / 15 ug/L = 200 day/L Now flip everything: 1/200 /day / L = 0.005 L/day CL = 0.005 L/day My answer is C. 
#3




corect answer:A)
If dose is about 3000 ug/day (Cp) is 15 ug/L then what will be the clearance?
corect answer: a) 200 L/day CL= maintaince dose / Cp CL= 3000 / 15 CL = 200 L/ day kaplan asesment test question. formulas for clearance of substance: CL = dose / Cp CL= free fraction x GFR CL=rate of drug eliminatation / Cp CL = Ke x vd mainatince dose = CL X Css x dosing interval / f Ko =CL X Css
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#4




Quote:
So this means that day/L is same thing as L/day and ug cancels out? 
#5




ya acording to explanation ug caceled out. thanks
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#6




Thanks for the Q
What are Ko and ke? 
#7




ok, i need some help here. i really do need to learn this stuff, because i ignored it the first time around, and i never got it.
i have the formula for Clearance: CL = rate of elimination of drug / plasma drug concentration so according to: CL = maintence dose/ Cp Does that mean Maintence dose = Rate of elimination of drug? what am i missing here? 
#8




i guess i don't understand this equation:
CL = dose / Cp 
#9




is it saying that the dose of 3000 per day is also the rate of elimination per day, since that is the amount given per day?
i'm really confused here, and i'm actually reviewing pharm right now! 
#10




More questions
Does anyone have a list of calculation questions that we can work on? These type of questions are few and far between in the question banks which makes it difficult to practice on and I def need the practice! Please help. Thanks

#11




Quote:
If you have a fraction over a fraction, and you're confused how to solve it. Simply invert the denominator and now mutiply it with the numerator.
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MedicalExaminer (03292013) 
#12




Quote:
i find ur explanations very useful
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#13




hey medicalexamer, could you please explain this concept for me? i understand the units, makes sense, but i don't get the equation. thanks!

#14




Quote:
The question stem was complex U can get cl from different equetions Cl=rate of elimination of drug/Cpthis equation is not useful in this particular case cause we dont know elimination rate cl can be calculated by VdxKe as well but we dont know the Ke (elimination constant) Third equation is maintenance dose=Cpxcl/f (as bioavailability is not given we assume its 100%=1) So maintenance dose=Cp x Cl as there is no other way of solving the equation, we assume above unitdose reffers to maintenance dose so Cl would equal maintenance dose devided by plasma drug concentration
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ReggieMiller (03292013), Weezy89 (05282014) 
#15




thanks!
so would you have to assume that biovailability is 100%? or was this info given in the question stem as an IV drug? from the info given, i wouldn't have known where to start! 
#16




ok, i think i'm getting a hang of this. tomorrow i'll do a quick run through. thanks.
the question says dose, but its actually a DOSAGE RATE (maintenence dose) that is given, which at steady state is equal to the elimination rate. i'm sure the question stem had to have mentioned 100% biovailablity, so that the denominator is 1. so now it makes much more sense. thanks! if possible, would someone mind posting the complete question for this? i just want to make sure i'm on the same wavelength here. it was just frustating because i had just finished doing pharmacokinestics earlier today, and was stumped with the question. as far as my explanation above goes, is that the correct reasoning/concept? 
#17




Quote:
There has been some new questions on this topic posted Practice on them
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ReggieMiller (03292013) 
#18




Quote:
a)5 L/DAY B)200 L /DAY C) 450 L/DAY and were other options Answer of this question is (B) : one need to calculate daily CL of hypericin in a patient who ingests 3mg/day. 100% bioavailability therefore one can conclude that all 3mg of hypericin have reached systemic circulation.if plasma conc: is 15ug/ml the clearance can b calculated by dividing the dose by concentration.it is important to note that the units for concntration must be same for dose and Cp. CL can be calculated as folows: CL = dose / Cp CL= 3000ug/day/15ug/L CL = 200 L /day. sorry i forgot from where i wrote this question on mine kaplan notes that was incomplete, today again i went thru question pool book and finaly i got it and posted here.
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#19




Thank you so much!!!!! 
#20




Quote:
There's nothing to be confused about. Let's walk here through. The question says if dose is about 3000 ug/day, plasma concentration (Cp) is 15 ug/L then what will be the clearance, right? So, first thing we do is list all the formulas. 1. t1/2 = 0.7 X Vd / Cl where Vd is volume of distribution. Cl is clearance. 0.7 is constant. t1/2 is half life. 2. Loading dose = Cp X Vd/F where Cp is plasma concentration. Cp is also Css. In other words, Loading dose = Css X Vd/F. Css and Cp are EXCHANGABLE. F is always 1 unless it is specify on the question stem. If question stem does not mention what is F, then it is 1. 3. Maintance dose = Cp X Cl/F Maintance dose = Css X Cl/F Again, Cp and Css are exchangable and they each mean the same. Also, F is always 1 UNLESS the question stem specifies what F is. If not, then F is 1. Now let's look at the problem again. If dose is about 3000 ug/day, plasma concentration (Cp) is 15 ug/L then what will be the clearance? We are given the following: Cp = 15 ug/L dose = 3000 ug/day. This could be loading dose or Maintance dose. We will find out when we will look at our final clue. The question ask what will be clearance? From here, we now know that the dose is maintance dose. Because only that equation involves clearance; and it is the clearance that we need to solve for. Rearrange the equation so that we can solve for Cl: Maintance dose = Cp X Cl/F Cl = F x Maintance dose/ Cp F = 1 because it did not specify in the stem. Cl = 1 X 3000 ug/day / 15 ug/ L Cl = 200 L/ day or day/ L. 
#21




Please Help
Medical Examiner please help!!
Q:if drug is known to be distributed into TBW, what dose (mg) is needed to obtain an initial plasma level of 5mg/L in patient weighing 70kg? a)210 b)150 c)110 d)50 e)35 The answer is 210, but i cant find a way to get there, please someone explain how do you get this answer?? 
#22




total body water 60 % of body . i.e 70*60/100 = 42L
loading dose = vd* cp 42*5 = 210 
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