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Old 03-29-2013
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Biochemistry LCAT and ACAT : Cholesterol metabolism.

As I encountered a question which got me confused, here's the matter:

I understand that LCAT is present in blood and is activated with apoA for unesterified Cholesterol(C) to Cholesterol Ester(CE) conversion and thus let the peripheral cholesterol be uptaken through HDL->LDL->Liver.

And that ACAT also C->CE in enterocytes for cholesterol packaging and in Liver for cholesterol storage.

Now, if a person is given a cholesterol rich meal, in which of the two conditions would the levels of C, the unesterified rise? With "LCAT deficiency or the ACAT deficiency"?

Thanks for using up the neuronal ATPs for my problems
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