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Old 04-01-2013
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Default Craniopharyngioma = growth retardation

Can someone explain the pathophysiology. Is it due to high prolactin (low testosterone), or is it due to low GH and TH.
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Old 04-01-2013
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Originally Posted by BharatDoc View Post
Can someone explain the pathophysiology. Is it due to high prolactin (low testosterone), or is it due to low GH and TH.

It's due to ABSENCE of Rathke's pouch. Rathke's pouch (Ectoderm) forms the Anterior Pituitary hormones:

TSH
FSH
LH
ACTH
GH
Prolactin
MSH

In Craniopharyngioma, Rathke's pouch is absent, Anterior pituitay is not formed and therefore these hormones are missing. All of them.
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Old 05-10-2014
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Default Craniopharyngioma explanation

With respect, I'm not sure if I understand/agree with Doctor Ali's answer. He says "Rathke's Pouch" is absent and therefore all the Anterior Pituitary hormones will be absent as well...

From what I've read, the tumor appears to arise from the remnants of Rathke's pouch, more specifically, epithelial cells of oral ectodermal origin. These epithelial cells are also odontogenic (tooth-forming), hence why we can often see calcifications as in the suprasellar mass. The mass may be cystic, solid, or calicified. In the case of cystic, it may be filled with yellow fluid rich in cholesterol crystals.

The mass itself may compress surrounding structures, and compression of the Anterior Pituitary may compromise the formation/release of GH, FSH, LH, TSH (etc), which could manifest as growth retardation. Medbullets also mentions that a decrease in ADH is possible, causing central DI and therefore excessive urination. Compression of the optic chiasm can of course lead to bitemporal hemianopia, which is also usually the case in pituitary adenoma.

ADults --> Pituitary ADenoma
Children --> Craniopharyngioma (presents in childhood, ages 5-10)


Please let me know if I'm mistaken.
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