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Old 04-01-2013
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Default The diastolic blood pressure is determined by the PVR and HR

Can somebody please explain to me why this is the case? Will help me understand more fully a concept I'm trying to understand, for Autonomic Pharmacology. Thanks!
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Old 04-01-2013
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ok, i have found where i took the notes from, i'll rewrite them here. hoping someone could help make sense out of this!



The Diastolic Blood Pressure is Mainly affected by PVR, and HR.

PVR (via alpha and beta2 receptors)
HR (b/c diastolic interval determines outflow of blood from the arterial compartment)

Pulse Pressure = Systolic - Diastolic

And Pulse Pressure is determined by Stroke Volume (a function of cardiac contraction, which is influenced by beta1 receptors)



So the Systolic Pressure = sum of Diastolic + Pulse Pressures, and is therefore a function of BOTH alpha and beta effects.




Note, this is in the context of actions of sympathomimetric drugs on the cardiovascular system
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