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Old 04-03-2013
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Blood DIC and Plasmin

DIC Lab Values:

Increase PT, PTT, Bleeding Time, Fibrin Split products (D dimers)
Decrease Platelet count, Fibrinogen, Factors 5 and 8

Okay I am fine with that. The question is "Why there is increase Plasmin generation?"
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Old 04-03-2013
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How did you get increased FDP (Fibrin Degradation Products)?

FDPs is the result of fibrin clot break down.

When you have too much fibrin clots you need the fibrinolytic system to break it down and therefore you need a lot of Plasmin to do that.

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Old 04-03-2013
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It is because in DIC activation of coagulation cascade occurs due to release of tissue thromboplastin or endothelial cell injury. Endothelial injury is going to expose subendothelial collagen and activation of Factor XII (Intrinsic system). Remember one of the activators of plasminogen is Factor XII. So, there is increase in plasmin levels.
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Last edited by mutant; 04-03-2013 at 12:38 PM.
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Old 04-03-2013
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Thanks guys!
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