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  #1  
Old 04-03-2013
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GIT Bile Salt Absorption!

58 year old male has significantly reduced reabsorption of bile salts resulting from the action of bile salt - binding resins. This is expected to lead to significant decrease in which of the following compounds?

A. Aldosterone
B. Cholestrol
C. Cortisol
D. Pregnenolone
E. Progesterone
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  #2  
Old 04-03-2013
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Er... Cholesterol?
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cholesterol (LDL)
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Old 04-03-2013
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so bile acids is not reabsorbed which will increase cholesterol production.which could increase aldosterone/cortisol/pregnelol.
but i dont think progesterone is the answer either.

okay im going with cortisol - dont ask me why.
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Cholesterol
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Old 04-03-2013
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Cholesterol.
Acting like cholestyramine or high fibre diet.
Hope I am thinking right.
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Old 04-03-2013
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bile acid resins decrease the enterohepatic circulation of bile acids thus decreasing the amount of bile acids required to make cholesterol. Liver will start making more bile acids instead of making cholesterol.
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Old 04-04-2013
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Quote:
Originally Posted by Doctor Ali View Post
58 year old male has significantly reduced reabsorption of bile salts resulting from the action of bile salt - binding resins. This is expected to lead to significant decrease in which of the following compounds?

A. Aldosterone
B. Cholestrol
C. Cortisol
D. Pregnenolone
E. Progesterone
cholesterol is significantly decreased..
but as all other options are produced from cholesterol their level also decreases..
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Quote:
Originally Posted by Doctor Ali View Post
58 year old male has significantly reduced reabsorption of bile salts resulting from the action of bile salt - binding resins. This is expected to lead to significant decrease in which of the following compounds?

A. Aldosterone
B. Cholestrol
C. Cortisol
D. Pregnenolone
E. Progesterone
i would say cholesterol ...
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Correct Answer Correct answer is B

Correct answer is Cholestrol. Bile acid resins cause increase excretion of bile salts in the stool. Because bile salts derive from conversion of cholesterol to bile salts in the liver, an upregulation of LDL receptors in hepatocytes results in extraction of cholesterol out of the blood; and synthesis of more bile salts.
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Quote:
Originally Posted by Doctor Ali View Post
Correct answer is Cholestrol. Bile acid resins cause increase excretion of bile salts in the stool. Because bile salts derive from conversion of cholesterol to bile salts in the liver, an upregulation of LDL receptors in hepatocytes results in extraction of cholesterol out of the blood; and synthesis of more bile salts.
true.. but den what levels will u expect of other products like pregnenolone, cortisol, aldosterone?? wont these level also decrese?
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Quote:
Originally Posted by nandish_m View Post
true.. but den what levels will u expect of other products like pregnenolone, cortisol, aldosterone?? wont these level also decrese?
Yes ur argument is right as well but as u rightly answered looking at the question concerning bile salt, The examiner wants to test the concept understanding regarding the relationship between bile salt and cholesterol levels in blood. Note also SIGNIFICANTLY. I agree the steroid hormones shd also be decreased.

Having said this we should understand the main regulators of steroid hormone synthesis. I think it's indirectly related to bile salt but directly related to.........
Hope am thinking right.
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