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Old 04-04-2013
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Drug Cellular Processes after Epinephrine

A 65 yr old male is hospitalized in ICU with septic shock. His B.P is 60/40mmHg despite aggressive intravenous hydration. Norepi is administered in response to patient's hypotension. Which of the following cellular process is seen with Norepi therapy?

A. cAMP increase in vascular smooth muscle cells
B. DAG decrease in vascular smc
C. cAMP increase in cardiac muscle cells
D. IP3 increase in cardiac muscle cells
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Old 04-04-2013
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C. cAMP increase in cardiac muscle cells (B1 receptor agonist)
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Old 04-04-2013
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Quote:
Originally Posted by nandish_m View Post
C. cAMP increase in cardiac muscle cells (B1 receptor agonist)
this was the question in uworld and the answer is correct. I wanted to know that Norepi also has effect of vasoconstriction via alfa1 .so why isnt the answer IP3 increase with Gq activation ?
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Old 04-04-2013
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i guess it says in cardiac muscle thats why..lol.
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Old 04-04-2013
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My answer is C. Norepinephrine works on alpha 1, 2 and beta 1 receptors.
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Old 04-04-2013
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wtf is norepi?
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Quote:
Originally Posted by bigBOSSguy View Post
wtf is norepi?
nvm, its norepinephrine...

answer is C...
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Old 04-04-2013
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C. B1 agonist via Gs receptors increase cAMP in cardiac muscles.

IP3 would be right if it stated that it increases in vascular cells.
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C. B1 agonist via cAMP pathway. It has alpha 1 activity too which increases TPR and causes vasoconstriction through IP3 which acts on vascular smooth muscles ( Gq coupled). The alpha 1 activity is more predominant than the beta 1 activity and there might be a chance of potential reflex bradycardia.
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