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Old 04-04-2013
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Help Heroin and Pulmonary edema

Heroin causes non-cardiogenic, exudative type of pulmonary edema. Anyone can explain the mechanism?

Also can you explain how acute mountain sickness causes pulmonary edema and cerebral edema?

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How can opiates be used to treat acute pulmonary edema when heroin causes pulmonary edema? Anyone?

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Old 04-04-2013
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founds this links: http://medicine.ucsf.edu/education/r...ry%20edema.pdf

Quote:
Narcotic overdose: From overdose of heroin or methadone. Usually occurs within 2 hours of injection. Pathophysiology unknown but believed due to direct toxicity, hypoxia, hyperventilation, or cerebral edema. Supportive measure for patient are indicated.
looks like its unknown. but it is noted that its for an overdose, perhaps that makes the difference between therapy and injury?

interested to see what others say on this.
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same link as above:

Quote:
High altitude pulmonary edema: etiology unclear but thought due to unequal pulmonary vasoconstriction and overperfusion of remaining vessels. Support patient and move to lower altitudes.
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Quote:
Originally Posted by mutant View Post
How can opiates be used to treat acute pulmonary edema when heroin causes pulmonary edema? Anyone?

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Again, from the same link.

Quote:
Morphine: give 2-5 mg over 3 minutes and repeat in 15 minutes if necessary. Decreases patient anxiety and work of breathing, thereby limiting sympathetic outflow and aiding in arteriolar and venous dilatation.
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Thanks ReggieMiller ....

Makes sense now.

But how cerebral edema occurs? I think increase in CO2 causes cebral vasodilation but at the same time hyperventilation sets in which decreases CO2 in the body.

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profound hypoxemia in altitude sickness causes cerebral vasodilation

remember in normal conditions CO2 regulates cerebral flow. Increased CO2 (hypoventilation) causes increased cerebral flow. Decreased CO2 (hyperventilation) causes decreased cerebral flow
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