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Old 04-05-2013
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Drug HIV protease inhibitors

How do protease inhibitors prevent maturation of new viruses? I don't understand the explanation in First Aid.
First Aid explanation "Assembly of virions depends on HIV-1 protease (pol gene) which cleaves the polypeptide products of HIV mRNA into their functional parts. Thus protease inhibitors prevent maturation of new viruses."

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Old 04-05-2013
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protease inhibitors prevent formation of structural proteins=no functional viral particle
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Old 04-06-2013
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Yes thats right, with no viral structural proteins, the virions can't mature into full viruses that can cause disease
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When viral mRNA is translated initially it is a large polypeptide chain that has to be cleaved by a protease into smaller proteins (post-translational modification), which then form virual structure.

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