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Old 04-09-2013
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DNA ribose/deoxyribose

how do we have dUMP (deoxyuridine monophosphate),dUDP and dUTP when we know that deoxy sugars are found only in DNA and URACIL base is found only in RNA?? i mean to say it should be simply UMP,UDP,UTP .....somebody plz clear my doubt
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Old 04-09-2013
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in DNA and RNA this order is maintained

but outside the nucleus u can see dUMP, dUDP, dUTP etc / besides dUMP in cytosol is required for thymine synthesis
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Old 04-11-2013
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Smile Ribose and deoxyribose sugars

Sugar phosphate ribose is attached to base in RNA and its deoxy form is found in DNA. RNA has purines (adenine and guanine) and pyrimidine (cytosine and uracil) whereas in DNA all these are same except for uracil which is replaced by thymine. Thymine which is used in DNA synthesis as TTP is synthesized from UMP (a uracil nucleotide). UMP is converted to UDP which undergo ribonucleotide reductase (RR) reaction to convert in dUDP which is later converted to dUMP, dUMP undergo thymidine synthase reaction to produce TMP (note that TMP is sometimes written as dTMP, but it is the same). TMP is converted to TDP and then to TTP by specific kinases and this TTP gets into DNA synthesis. As you asked, generally we don't see dUTP as it is not a part of DNA. Hope this helps!!

Dr Mungli
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