ribose/deoxyribose - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

Thread Tools Search this Thread Display Modes
Old 04-09-2013
USMLE Forums Scout
Steps History: Not yet
Posts: 13
Threads: 4
Thanked 3 Times in 3 Posts
Reputation: 13
DNA ribose/deoxyribose

how do we have dUMP (deoxyuridine monophosphate),dUDP and dUTP when we know that deoxy sugars are found only in DNA and URACIL base is found only in RNA?? i mean to say it should be simply UMP,UDP,UTP .....somebody plz clear my doubt
Reply With Quote Quick reply to this message

Old 04-09-2013
MedicalExaminer's Avatar
USMLE Forums Master
Steps History: 1+CK+CS+3
Posts: 824
Threads: 66
Thanked 457 Times in 296 Posts
Reputation: 467

in DNA and RNA this order is maintained

but outside the nucleus u can see dUMP, dUDP, dUTP etc / besides dUMP in cytosol is required for thymine synthesis
Everything is possible for him who believes (MARK 9:23)
245/247/passed on 1st attempt/223/2mos Obsie /3 US LORS/visa not needed/2008 grad
Reply With Quote Quick reply to this message
The above post was thanked by:
raghuvanshi (04-09-2013)
Old 04-11-2013
Dr Mungli's Avatar
USMLE Forums Newbie
Steps History: ---
Posts: 7
Threads: 0
Thanked 5 Times in 4 Posts
Reputation: 15
Smile Ribose and deoxyribose sugars

Sugar phosphate ribose is attached to base in RNA and its deoxy form is found in DNA. RNA has purines (adenine and guanine) and pyrimidine (cytosine and uracil) whereas in DNA all these are same except for uracil which is replaced by thymine. Thymine which is used in DNA synthesis as TTP is synthesized from UMP (a uracil nucleotide). UMP is converted to UDP which undergo ribonucleotide reductase (RR) reaction to convert in dUDP which is later converted to dUMP, dUMP undergo thymidine synthase reaction to produce TMP (note that TMP is sometimes written as dTMP, but it is the same). TMP is converted to TDP and then to TTP by specific kinases and this TTP gets into DNA synthesis. As you asked, generally we don't see dUTP as it is not a part of DNA. Hope this helps!!

Dr Mungli
Reply With Quote Quick reply to this message
The above post was thanked by:
raghuvanshi (04-11-2013)



Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2016 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)