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  #1  
Old 04-09-2013
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Biochemistry Old Grad Biochemistry Trouble!

I aced biochem back in med school. but its been a very long time, so i forgot a lot!!

reading kaplan just seems so basic though. but i do understand every page of the kaplan book, and i don't need other sources. is this a good sign?

but here's what worries me: e.g.) for PDH complex, there are 3 subunits E1-3. and E1 is reguated by 2 other enzymes, which either phosophrylate (deactivate) or dephosphorylate (activate) the E1 component (which happens to be the dehydrogenase).

i recall that acetyl CoA, and NADH activates the Kinase (which phosphorylates E1), and therefore, the phosphorylated E1 becomes deactivated. So in short, Acetyl CoA and NADH inhibit PDH Complex.



But in the Kaplan book, it basically just filters out the fluff, and simply states Acetyl CoA inhibits PDH Complex.



I wouldn't have known the 'more complicated' mechanism, had i not looked it up. so is it really enough to know just what is in kaplan biochemistry? Back in med school i remember doing all these complicated pathways, including learning exactly HOW PDH complex works. but the kaplan lecture notes is very very very basic.


pls help, i'm a very paranoid person when it comes to reviewing comprehensively!!!


Bottom Line: As long as i understand what the Kaplan Lecture Notes is saying, and I can completely follow along with the Video Lectures, then am I on the right track here???


apologies for the very long post.
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  #2  
Old 04-09-2013
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Originally Posted by ReggieMiller View Post
I aced biochem back in med school. but its been a very long time, so i forgot a lot!!

reading kaplan just seems so basic though. but i do understand every page of the kaplan book, and i don't need other sources. is this a good sign?

but here's what worries me: e.g.) for PDH complex, there are 3 subunits E1-3. and E1 is reguated by 2 other enzymes, which either phosophrylate (deactivate) or dephosphorylate (activate) the E1 component (which happens to be the dehydrogenase).

i recall that acetyl CoA, and NADH activates the Kinase (which phosphorylates E1), and therefore, the phosphorylated E1 becomes deactivated. So in short, Acetyl CoA and NADH inhibit PDH Complex.



But in the Kaplan book, it basically just filters out the fluff, and simply states Acetyl CoA inhibits PDH Complex.



I wouldn't have known the 'more complicated' mechanism, had i not looked it up. so is it really enough to know just what is in kaplan biochemistry? Back in med school i remember doing all these complicated pathways, including learning exactly HOW PDH complex works. but the kaplan lecture notes is very very very basic.


pls help, i'm a very paranoid person when it comes to reviewing comprehensively!!!


Bottom Line: As long as i understand what the Kaplan Lecture Notes is saying, and I can completely follow along with the Video Lectures, then am I on the right track here???


apologies for the very long post.

man dont overload ur brain with stuff that has nothing to do with exam
focus on highest yield info which is already a burden
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Old 04-09-2013
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Originally Posted by MedicalExaminer View Post
man dont overload ur brain with stuff that has nothing to do with exam
focus on highest yield info which is already a burden
Thanks ME. I think I've started my preparation (for biochem) wrong, and in an attempt to save all those hours reviewing all the pathways, enzymes, etc, I'm trying to justify to myself, that I need to go over it all.

But I think I may have to take a hit here, put all those notes I wrote down, put them aside, and just stick with the Kaplan lecture notes. Like you said, there is enough material we have to know anyways. Even if I continued with my method, it wouldn't be feasable. Thanks for the wake up call!

(this is my second wake up call - i didn't listen the first time). but this time i'm taking it seriously. ONLY FOCUSING ON KAPLAN LN's FROM NOW ONWARDS!!!!

(except for patho - RR, and micro - CMMRS)

immuno - will do from kaplan too.


thanks again!
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Old 04-11-2013
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Smile Partial Solution for your Biochem problem!!

Biochemistry is little volatile and unless constantly revised!! You can take a look at my YouTube channel where I reviewed some of the biochemistry concepts which may be interesting to you. My channel be found by typing my name Dr Mungli in YouTube or you can type my full name Prakash Mungli.

Hope and wish that helps you partly!!


Dr Mungli
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Old 04-11-2013
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Quote:
Originally Posted by ReggieMiller View Post
I aced biochem back in med school. but its been a very long time, so i forgot a lot!!

reading kaplan just seems so basic though. but i do understand every page of the kaplan book, and i don't need other sources. is this a good sign?

but here's what worries me: e.g.) for PDH complex, there are 3 subunits E1-3. and E1 is reguated by 2 other enzymes, which either phosophrylate (deactivate) or dephosphorylate (activate) the E1 component (which happens to be the dehydrogenase).

i recall that acetyl CoA, and NADH activates the Kinase (which phosphorylates E1), and therefore, the phosphorylated E1 becomes deactivated. So in short, Acetyl CoA and NADH inhibit PDH Complex.



But in the Kaplan book, it basically just filters out the fluff, and simply states Acetyl CoA inhibits PDH Complex.



I wouldn't have known the 'more complicated' mechanism, had i not looked it up. so is it really enough to know just what is in kaplan biochemistry? Back in med school i remember doing all these complicated pathways, including learning exactly HOW PDH complex works. but the kaplan lecture notes is very very very basic.


pls help, i'm a very paranoid person when it comes to reviewing comprehensively!!!


Bottom Line: As long as i understand what the Kaplan Lecture Notes is saying, and I can completely follow along with the Video Lectures, then am I on the right track here???


apologies for the very long post.

I will also confirm that don't worry with all those low yield details. u know the high yield materials already as u have mentioned. Most of us even think Kaplan notes are already detailed enough and want to cut some things out but becos of fear we are forced to read then anyway so don't burden urself with low yield material my friend.
I had big time trouble recalling most of the pathways and even their appendages I mean inhibitors etc. so if u can recall those in Kaplan easily then u are way doing fine so keep it up. Remember biochem has been voted the most difficult subject as at now in this forum.
All the best.
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