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Old 04-10-2013
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RBC Where is AST in RBCs?

Aspartate aminotransferase is a mitochondrial enzyme... RBCs don't have a mictochondria so where is it located in RBCs?
What you seek is seeking you Rumi
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Old 04-11-2013
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Smile Location of AST!!

AST can be found in two locations, cytoplasm and mitochondria. In RBC it is found in cytoplasm. Where as in other cells, specially in liver, it can be found both in cytoplasm and mitochondria. During hemolysis you see increase in serum AST. Where as in liver injury, specially alcoholic liver injury, will lead to hepatocyte cell membrane damage leaking cytoplasmic AST and also alcohol will damage mitochondria thereby releasing mitochondrial AST. This is the reason why alcoholic liver disses elevates AST more than ALT!!!

Hope this helps,

Dr Mungli
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