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Old 04-10-2013
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DNA Chromosomal Translocation

A 40-year-old man presents to the emergency department with 8 hours of uncontrollable epistaxis. In the past 3 months he has felt increasingly fatigued, and has lost 11.3 kg (25 lb). On physical examination, he is pale and is found to be bleeding from his gingivae. He also has diffuse petechiae on his skin. His complete blood cell count results demonstrate pancytopenia. Coagulation tests demonstrate a prothrombin time of 20 seconds, and a partial thromboplastin time of 45 seconds. His fibrinogen is 50 mg/dL (normal: 123-370 mg/dL). A bone marrow aspirate is performed, which demonstrates an increased number of leukocyte precursor cells, many of them containing red-staining rods in the cytoplasm.

What chromosomal translocation is characteristic of this patientís disease?

A. t(8;14)
B. t(9;22)
C. t(11;14)
D. t(11;22)
E. t(12;21)
F. t(15;17)
G. t(14;18)

If you guys know the answer try to think about the disorders associated to the different translocations, as a mental exercise.
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Old 04-10-2013
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answer: F (AML with auer rods described in the question is in subtype M3 with translocation 15;17)

A. burkitts
B. CML
C. Mantle
D. ewings sarcoma
E. ALL (good prognosis)
F. AML (M3)
G. Follicular lymphoma
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Old 04-11-2013
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This patient has pancytopenia, DIC, & red staining rods = AML; and that will be t 15:17.
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Old 04-11-2013
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Hi guys check what I posted here
http://www.usmle-forums.com/usmle-st...locations.html
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Genetics-, Hematology-, Pathology-, Step-1-Questions

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