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Old 04-13-2013
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Immunology Complement system confusion

Which pathway is activated by immune-complexes - Alternative or classical pathway? Can anyone make it easy, I don't understand this concept?
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classic complement pathway is activated by IgG and IgM.. IgM being the stronger activator because it has many arms .. while IgG is divalent.
FA has a simple figure for the complement system in immunology section
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Old 04-14-2013
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Quote:
Originally Posted by ` Faith ` View Post
classic complement pathway is activated by IgG and IgM.. IgM being the stronger activator because it has many arms .. while IgG is divalent.
FA has a simple figure for the complement system in immunology section
Here is what I have read in Goljan,

1. IgA nephropathy - Mesangial IgA IC* deposits; ICs activate alternative complement pathway.

2. Post-streptococcal GN - subepithelial IC deposits; ICs activate alternative complement pathway.

3. Diffuse proliferative GN - subendothelial IC deposits; DNA-anti-DNA ICs activate classical complement pathway.

Why first two activate alternative pathway and third one activates classical pathway? What is the mechanism here?

IC = immune complex

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