classic complement pathway is activated by IgG and IgM.. IgM being the stronger activator because it has many arms .. while IgG is divalent.
FA has a simple figure for the complement system in immunology section
1. IgA nephropathy - Mesangial IgA IC* deposits; ICs activate alternative complement pathway.
2. Post-streptococcal GN - subepithelial IC deposits; ICs activate alternative complement pathway.
3. Diffuse proliferative GN - subendothelial IC deposits; DNA-anti-DNA ICs activate classical complement pathway.
Why first two activate alternative pathway and third one activates classical pathway? What is the mechanism here?
IC = immune complex
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