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Old 04-20-2013
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Help How insulin retains Na+?

Insulin causes hypertension by retaining Na+ in renal tubules. Can you guys explain the mechanism of Na+ retention?
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Old 04-20-2013
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Another question:

Hypothyroidism cause Diastolic HTN by causing retention of Na+ and water. How Na+ is retained and isn't it supposed to be Systolic HTN b/c increase in blood volume increase venous return so stroke volume increase. Diastolic BP is dependent on TPR.

Any body please answer both Qs?
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Old 07-06-2013
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Could not find answers yet...
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Old 07-07-2013
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i have learnt so much from your questions!

Quote:
Originally Posted by mutant View Post
Insulin causes hypertension by retaining Na+ in renal tubules. Can you guys explain the mechanism of Na+ retention?
http://books.google.com/books?id=R50...hanism&f=false

There's a lot of stuff going on in the above link, but here's how I choose to remember it: Insulin induces the insertion of Na/K ATPase pumps in cell membranes. Recall that in the Kidney Tubules, those Channels are on the basolateral side.

So you're gonna get more channels, that activiely pump 'out' Na...and into the blood.

I don't know why, but I always associate Insulin's action on inserting these Na/K ATPase pumps with eating a banana. after you eat, rise in glucose stimulates insulin, which pushes all that glucose back into cells. but potassium is also regulated, which can be explained by the action of Insulin too - which insert those Na/K ATPase channels...which helps remove any 'K' from the banana.

So it's the same way with the action of Insulin on the Kidneys, but this time, we're looking at reabsorption of Na. So it's the same thing, but a different context.
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Old 07-07-2013
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I saw your next question, and really felt stumped again! but saw that the question involved SODIUM so i checked out that link again, and right beneath the explanation for your first question, was this:

http://books.google.com/books?id=R50...ryroid&f=false (scroll down to the next page "other factors")

But as far as increased diastolic pressures go, looks like it's associated with increased arterial stiffness, which would make more sense: http://www.medscape.com/viewarticle/733788_3

btw, where are you getting these concepts from? they are very interesting! are they from any qbank questions?
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Old 07-07-2013
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Thank you Reggie! You always come up with a simple answer to my questions.

I read these concepts in Goljan RR, but the mechanism isn't explained! I was reviewing physiology and again same questions arose.

Most of the Qs are from Kaplan or Goljan. sometimes concepts are not explained well enough so I put questions on this forum to see how can these things be correlated.
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Cardiovascular-, Electrolytes-, Endocrine-, Physiology-

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