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  #1  
Old 04-24-2013
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Microscope Metaplasia Vs. Dysplasia

Hey guys can someone explain these to me. It seems like such an easy concept I keep reading it over and over and seem to mix up what GERD and Barrett's falls under!

I know metaplasia is a replacement of one cell type to another.
Dysplasia- is abnormal cells lacking differentiation (copying from first aid)

If anyone could clear this concept for me that would be great

Also why would myometrial growth be considered hypertrophy and not hyperplasia?
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Old 04-24-2013
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from what i remember of this, dysplastic cells result from lack of differentiation into mature cells. they don't mature completely. that's dysplasia.

and ur right about metaplasia, which is one differentiated type is replaced by another cell, which is also differentiated.

may have to just go through the defnitions in a path book just for clarrification. i think more important, is to rememember examples of metaplasia vs dysplasia.
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Old 04-24-2013
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Thank you!

The only problem is when I do questions like myometrial proliferation.. I assume that its like endometrial hyperplasia, hence hyperplasia. But then when I look at the answer its hypertrophy and I dont know why.

lol I think I need to watch pathoma again I did it 5 months ago, so really need to freshen it up
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Old 04-25-2013
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Quote:
Originally Posted by aspiringdoctor View Post
Hey guys can someone explain these to me. It seems like such an easy concept I keep reading it over and over and seem to mix up what GERD and Barrett's falls under!

I know metaplasia is a replacement of one cell type to another.
Dysplasia- is abnormal cells lacking differentiation (copying from first aid)

If anyone could clear this concept for me that would be great

Also why would myometrial growth be considered hypertrophy and not hyperplasia?
Your dysplasia and metaplasia concepts are alright. To help you remember, think about dysplasia as already cancer in situ, meaning that the cells are all screwed up,lacking differentiation and going berserk, its irreversible, not benign.

In metaplasia, its just a change of tissue, like for example a change from columnar epithelium to gastric, or the most common metaplasia is in the cervix, where there is a physiologic change of cell type in the transitional zone of the cervix. (In a Pap test, you might read metaplasia, and its normal, its benign, but if dysplasia is present, then something is wrong).

As for your myometrial growth question, I have the idea that all tissue that is muscle will do hypertrophy or hypotrophy, therefore the myometrium undergoes that type of change, which is an increase in cell size. (think about your muscle when going to the gym, it increases in size ). Compare with other tissue like adrenocortical tissue which when overstimulated, undergoes hyperplasia, it needs more cells to meet the demands, it increases in number.

Hope it helps...
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Old 04-25-2013
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Default thanks!

Thank you so much for the clarification I guess I just need more practice questions lol
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Old 04-26-2013
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D-ysplsia : D-isordered growth of a cell
MET-aplasia : i MET someone and they CHANGED my life .

so CHANGE of one cell type to another . for eg , CHANGE of lower end of esophagus to goblet cells and mucus secreting cells on exposure to acidic ph of stomach in GERD.


i dunno how much that will help but that's how i remember it . hope this helps
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Old 04-26-2013
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Quote:
Originally Posted by medpack87 View Post
Your dysplasia and metaplasia concepts are alright. To help you remember, think about dysplasia as already cancer in situ, meaning that the cells are all screwed up,lacking differentiation and going berserk, its irreversible, not benign.

In metaplasia, its just a change of tissue, like for example a change from columnar epithelium to gastric, or the most common metaplasia is in the cervix, where there is a physiologic change of cell type in the transitional zone of the cervix. (In a Pap test, you might read metaplasia, and its normal, its benign, but if dysplasia is present, then something is wrong).

As for your myometrial growth question, I have the idea that all tissue that is muscle will do hypertrophy or hypotrophy, therefore the myometrium undergoes that type of change, which is an increase in cell size. (think about your muscle when going to the gym, it increases in size ). Compare with other tissue like adrenocortical tissue which when overstimulated, undergoes hyperplasia, it needs more cells to meet the demands, it increases in number.

Hope it helps...
Is dysplasia irreversible? In Pathoma lectures, Dr. Sattar says that dysplasia is reversible! Which one is correct?
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Old 04-26-2013
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Originally Posted by mutant View Post
Is dysplasia irreversible? In Pathoma lectures, Dr. Sattar says that dysplasia is reversible! Which one is correct?
I Have been looking around and some sources say its reversible and other irreversible. Some say it depends on the grade, since dysplasia can be graded. If the pathoma lectures say its reversible then I would go for that. Sorry for the confusion
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