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Old 05-01-2013
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Default can someone explain why nucleotides accumulate when phosphate concentration goes down?

i'm going through my kaplan notes, and don't know if i really understood this point. concentration of free phosphate decreases in conditions like galactosemia, HFI, and G6PD def.

But how does the decreased level of phosphate cause an accumulation of nucleoside monophosphates?

is there a feedback mechanism somewhere that i forgot about?
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Old 05-01-2013
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hi ,
as far as i know ,the amp which is formed in the cell cannot be phosphorylated to adp or atp because phosphate level decreases in the above causes ...like in hfi the substrate f-1-p takes up the available phosphate ...
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Old 05-01-2013
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Quote:
Originally Posted by kishore View Post
hi ,
as far as i know ,the amp which is formed in the cell cannot be phosphorylated to adp or atp because phosphate level decreases in the above causes ...like in hfi the substrate f-1-p takes up the available phosphate ...
ah! that makes perfect sense, thank you!
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